7 days in healthcare (August 12th-18th, 2024)
Summary
Biomedicine
- The Lancet provides a clinical update on persistent covid. Defined as symptoms that persist for more than three months. Although the approach is based on symptoms, work is being done on identifying the molecular profile and biomarkers.
- There is no benefit for adults who drink alcohol in moderation. A long study shows that adults have no benefit from moderate alcohol consumption. After following 135,103 adults over 60 years of age, the conclusion is that alcohol is associated with increased cancer and does not produce the benefits on the heart that were attributed to it for some time.
Global Health
- The WHO declares the Mpox outbreak in African countries a global emergency. Despite the severity, there are two facts that differentiate this outbreak from that of covid: the first is that the infection is not transmitted through the air, with the great difficulties of control that this entails, but by direct contact; the second is that this time there are already vaccines and many countries, such as Spain, have them in stock. We are not, therefore, facing a pandemic threat like the one we saw a few years ago.
- Vaccine shortages threaten the response to Mpox. The outbreak has been detected in 13 African countries, most of them in the Democratic Republic of Congo. Concerns about vaccine supply and distribution come after similar problems during Covid. Bavarian Nordic, the only company producing this vaccine, received an order for more than 175,000 doses from the EU Emergency Preparedness and Response Centre (HERA) and, for its part, donated 40,000 vaccines to HERA. But with vaccine shortages, other measures must be taken, such as contact control and testing. The seriousness of the failure of the WHO and the international community in the face of the Pandemic Treaty is now being seen.
- High heat-related mortality in Europe during 2023. This year was the hottest globally on record and the second hottest in Europe. An estimated 47,690 heat-related deaths in Europe are estimated. Mortality is estimated to have been 80% higher in the absence of adaptation measures this century, especially for the elderly. Specific strategies are needed to address this major threat.
- 4.4 billion people lack safe water. This requires three requirements: available on demand; accessible in homes and free of contaminants, such as Escherichia coli and specific chemicals.
International health policy
- Agreement on the price of 10 drugs in the USA. Biden and Harris announce savings of 7.5 billion dollars, as a result of the agreement on the change in the price of 10 drugs. The affected companies are not minor: Merck, NovoNordisk, AstraZeneca, Immunex, Boehringer Ingelheim, Janssen, BMS, Novartis, AbbVie, among others.
- The Lancet sets out Kamala Harris’s health priorities in an editorial. The first thing to recognize is Biden’s merits in health policy: reestablishing funding for the WHO and the UN Fund for the population; returning to the Paris agreement on climate change (both Trump eccentricities); increasing credits for children; expanding Obamacare; and approving the law to reduce inflation (which has allowed the price agreement with the pharmaceutical industry). According to this editorial, Kamala Harris’ priorities would be four: 1. Reverse the decline in life expectancy in the USA (77.4 years in 2022, compared to 78.8 in 2019). The State of Mississippi has a life expectancy of 71.9 years, lower than Mongolia (72.6 years) and Syria (72.3 years); 2. Incentivize States with the poorest health indicators; 3. Regain confidence in science, lost by a large part of the population; and, 4. Strengthen the role of the USA in global health diplomacy. • The NHS launches a subscription system for antibiotics. The NHS will negotiate with pharmaceutical companies a subscription system of up to 20 million pounds per year per medicine. The tender will be launched next Monday and will reach 1.9 billion pounds in 16 years and will operate in the four nations of the United Kingdom.
- The NHS “Pharmacy First” is not working properly. Pharmacies do not reach the minimum number of consultations. In the programme, seven specific pathologies had been defined to be attended to by pharmacies, which would receive extra payment. The programme is not working as well as expected, in the eyes of the pharmacies attached to the initiative.
- Health strategies in the European Union are not given priority. According to an editorial in The Lancet Regional Health-Europe.
National Health Policy (Spain)
- Spain faces Mpox. The Ministry of Health brings together technicians and autonomous communities in response to the Mpox health emergency and negotiates with the European Union the joint purchase of smallpox vaccines. It is known that the cases registered in Spain are unvaccinated people.
- Health will reduce the time for drug approval. The Royal Decree that will define from now on the process of approval and financing of drugs has been made public. Deadlines are established for the approval of a new drug, which will go from the current average of 650 days to 210 days, a substantial change.
- Extraordinary good reception of the Minister Olga Pané by the Catalan health sector. Some comments on this:
- Apart from the outstanding qualities of the new Minister, it is not precisely the lack of competent councillors that has been seen in Catalonia. What was lacking was rather a good government concerned about “things”, as Ortega would say. Without a good government (with a project and willing to carry out a reformist project) there can be no success in health policy.
- Catalonia can make an important contribution to its system and to the national system if it advances in the reform of the public management model and in personnel policy, key issues for the Catalan Society of Health Management, to which the minister is linked.
- Far from emphasizing these issues, the PSC-ERC agreement insists above all on an endless list of infrastructure works, which apart from being difficult to fulfill, rather seems something similar to Gonzalo Fernández de la Mora’s “State of Works”. Logically, a plan for works is not a health policy. On the other hand, in this same section there is talk of “continuing with the processes of republification”, the scope of which is not specified, but which may contain worrying connotations.
Companies
- International
- Eight super drugs will lose their patent in the next five years. This affects Merck-MSD, BMS, Bayer, Pfizer, Lilly or Roche. The eight blockbusters that will lose their patent at the end of this decade are among the thirty best-selling drugs in the world.
- Who is Bavarian Nordic, the company that makes the only vaccine against Mpox. It rises 38% on the stock market in four days. The CEO of this company, Paul Chaplin, assured that it will be able to meet the immunization needs of African nations. “We have inventory and we have the capacities. What we lack are the orders,” he said.
- National
- Problems continue at Grifols. Stock market crash and demand in the USA.
Biomedicine
- AI scientists are producing new theories about how the brain works in learning. The complexity is such that the brain contains billions of neurons, of which millions can be involved in a single activity (https://www.economist.com/science-and-technology/2024/08/14/ai-scientists-are-producing-new-theories-of-how-the-brain-learns)
- A new neuroprosthesis for language. An article in the NEJM presents how a person with amyotrophic lateral sclerosis and dysarthria, an intracortical device allows him to recover communication skills in a conversation (https://www.nejm.org/doi/full/10.1056/NEJMoa2314132)
- Long Covid: a clinical update, defined as symptoms that persist for more than three months. Although the approach is based on symptoms, work is being done on identifying the molecular profile and biomarkers (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01136-X/abstract#:~:text=Supplementary%20Material-,Summary,a%20result%20of%20organ%20damage.)
- A long study shows that there are no benefits for adults in moderate alcohol consumption. After following 135,103 adults over 60 years of age, the conclusion is that alcohol is associated with an increase in cancer and does not produce the benefits for the heart that were attributed to it for some time. (https://www.nytimes.com/2024/08/12/health/alcohol-cancer-heart-disease.html). Access to the original JAMA article: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822215#:~:text=While%20no%20associations%20were%20found,higher%20all%2Dcause%20(HR%2C
Global Health
- WHO declares the Mpox outbreak in African countries a global emergency (https://www.nytimes.com/2024/08/14/health/mpox-who-emergency-africa.html). Despite the severity, there are two facts that differentiate this outbreak from that of Covid: the first is that the infection is not transmitted through the air, with the great difficulties of control that this entails, but by direct contact; the second is that this time there are already vaccines and many countries, such as Spain, have them in stock. We are not, therefore, facing a pandemic threat like the one we witnessed a few years ago. Access to the official WHO report, published on August 12, 2024: https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox–external-situation-report-35–12-august-2024
- Vaccine shortage threatens the response to Mpox. The outbreak has been detected in 13 African countries, mostly in the Democratic Republic of Congo. Concerns about vaccine supply and distribution follow similar problems during Covid. Bavarian Nordic, the only company producing this vaccine, received an order for more than 175,000 doses from the EU Emergency Preparedness and Response Centre (HERA) and, for its part, donated 40,000 vaccines to HERA. But with vaccines in short supply, other measures must be taken, such as contact tracing and testing (https://www.ft.com/content/47e34535-2fe5-4a87-a255-2a17c1e2e8fd)
- How dangerous is Mpox as a public emergency? Mpox is a viral disease, of zoonotic origin, transmitted from animals. The virus involved in the 2022-2023 outbreaks was produced by a different type of virus. The current one is more dangerous, as it spreads more quickly (https://www.ft.com/content/6b6781d3-60f4-4f3f-98cb-1719782c4a7a)
- The Mpox epidemic has caused 548 deaths since the beginning of the year in the Democratic Republic of Congo (https://www.lemonde.fr/afrique/article/2024/08/15/l-epidemie-de-mpox-a-fait-548-morts-depuis-le-debut-de-l-annee-en-rdc_6282424_3212.html#:~:text=In%20Democratic%20Republic%20of%20Congo%20(RDC)%20in%20particular%20%3A%20d,debut%20of%20the%20year».)
- Heat-related mortality in Europe in 2023. This year was the warmest year on record globally and the second warmest in Europe. An estimated 47,690 heat-related deaths in Europe. It is estimated that mortality would have been 80% higher in the absence of adaptation measures this century, especially for the elderly. Specific strategies are needed to address this major threat (https://www.nature.com/articles/s41591-024-03186-1)
- Courts and climate change. In the coming months, the United Nations Court of Justice, based in The Hague (Netherlands), will analyze the consequences of climate change from two perspectives: first, what are the obligations of countries to protect climate change and, second, what legal consequences can be established in cases of infringement (https://www.nature.com/articles/d41586-024-02600-5.pdf)
- 400 million people lack safe water. This requires three requirements: available on demand; accessible in homes and free of contaminants such as Escherichia coli and specific chemicals (https://www.science.org/doi/10.1126/science.adr3271)
- The ongoing struggle for oral health. Nearly half of the world’s population lives with one or more oral problems. Even in countries with universal health coverage, dental care is provided out of pocket. Public funding of dental coverage has enormous potential, as demonstrated in Thailand and Brazil. Ultra-processed foods and tobacco, a threat to oral health, affecting industries with huge profits (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00536-1/abstract)
International health policy
- USA
- Biden and Harris announce savings of 7.5 billion dollars, as a result of the agreement on the change of prices of 10 drugs. The affected companies are not minor: Merck, NovoNordisk, AstraZeneca, Immunex, Boehringer Ingelheim, Janssen, BMS, Novartis, AbbVie, among others. (https://www.ft.com/content/718b52e8-9c57-4dcf-b2f4-84cf8d7da21c)
- The Lancet editorial: Kamala Harris’s health priorities. The first thing to recognize are Biden’s merits in health policy: reestablishing the funding of the WHO and the UN Fund for the population; returning to the Paris agreement on climate change; increasing credits for children; expanding Obamacare; and approving the law to reduce inflation (which has allowed the price agreement with the pharmaceutical industry). According to this editorial, Kamala Harris has four priorities: 1. Reverse the decline in life expectancy in the USA (77.4 years in 2022, compared to 78.8 in 2019). The state of Mississippi has a life expectancy of 71.9 years, lower than Mongolia (72.6 years) and Syria (72.3 years); 2. Incentivize states with the poorest health indicators; 3. Restore trust in science, lost by a large part of the population; and, 4. Strengthen the role of the USA in global health diplomacy (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01687-8/fulltext)
- Medicare expansion of obesity drugs could mean an increase in spending of between 3.1 and 6.1 billion dollars (https://www.healthaffairs.org/doi/10.1377/hlthaff.2024.00356)
- United Kingdom and the National Health Service
- The NHS launches a subscription system for antibiotics with the pharmaceutical sector. The NHS will negotiate a subscription system of up to 20 million pounds per year per drug. The competition will be launched next Monday and will reach 1.9 billion pounds in 16 years and will operate in the four nations of the United Kingdom (https://www.ft.com/content/f64170fe-ccd9-4854-b37a-00469c53b996)
- “Pharmacy First”, pharmacies do not reach the minimum number of consultations. In the program, seven specific pathologies had been defined to be attended to by pharmacies, which would receive extra compensation. The program is not working as well as expected, in the eyes of the pharmacies attached to the initiative (http://www.diariomedico.com/farmacia/comunitaria/pharmacy-first-farmacias-llegan-minimo-consultas-cobrar-servicio.html)
- France
- France wants to advance in investments in palliative care and legalize assisted death. A new draft legislation will be submitted to the new Assembly (https://eurohealthobservatory.who.int/monitors/health-systems-monitor/updates/hspm/france-2023/end-of-life-care-draft-bill-france-plans-to-further-invest-in-palliative-care-and-legalize-assisted-death)
- European Union
- Health strategies are not prioritized in the European Union, according to an editorial in The Lancet Regional Health-Europe (https://www.consalud.es/politica/union-europea-salud-pincha-estrategias-no-dan-prioridad_147372_102.html). Access to the original editorial: https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(24)00185-6/fulltext
- The EU will meet on August 19 to discuss the Mpox emergency (https://www.consalud.es/politica/ue-se-reunira-proximo-19-agosto-discutir-actuaciones-emergencia-por-mpox_147514_102.html)
- The European Commission responds to the Mpox outbreak and will buy and donate more than 215,000 doses of vaccines (https://www.consalud.es/pacientes/comision-europea-responde-brote-mpox-vacuna_147509_102.html)
- EU rules threaten the development of new treatments for rare diseases (https://www.ft.com/content/c5dbb944-4e7b-4851-ba72-2a07252ec54a)
National health policy
- Central government initiatives
- The Ministry of Health brings together technicians and autonomous communities in the face of the health emergency caused by Mpox (https://www.alimente.elconfidencial.com/bienestar/2024-08-15/sanidad-reune-viruela-mono-emergencia-global_3943550/)
- Spain negotiates with the European Union the joint purchase of smallpox vaccines (https://www.abc.es/sociedad/espana-negocia-compra-conjunta-vacunas-viruela-20240816195535-nt.html)
- An office attached to the AEMPS will carry out the economic evaluations of the medicines (https://diariofarma.com/2024/08/12/una-oficina-adscrita-a-la-aemps-hara-las-evaluaciones-economicas-de-medicamentos)
- Health exposes the text for objections of the Royal Decree on Health Technology Assessment (https://diariofarma.com/2024/08/12/sanidad-expone-para-alegaciones-el-texto-de-rd-de-evaluacion-de-tecnologias-sanitarias
- Health will reduce the time for drug approval from 650 to 210 days. The Royal Decree that will now define the process for drug approval and financing has been made public. Deadlines are set for the approval of a new drug, which will go from the current average of 650 days to 210 days, a substantial change (https://www.eleconomista.es/salud/noticias/12945993/08/24/sanidad-reducira-de-650-a-210-dias-el-tiempo-de-aprobacion-de-medicamentos.html#:~:text=Sanidad%20reducirá%20de%20650%20a%20210%20días%20el%20tiempo%20de%20aprobación%20de%20medicamentos,-Creará%20). Text of the RD submitted for consultation: https://www.sanidad.gob.es/normativa/audiencia/docs/TEXTO_Y_MAIN_RD_FINANCIACION_PPSS_PARA_IP_Y_TA.pdf
- Initiatives and news from the autonomous communities
- The new Minister of Health of Catalonia, Olga Pané, has been extraordinarily well received by the Catalan health “intelligentsia” (Villaplana, Ortún, Cunillera), which, apart from the outstanding qualities of the new minister, contrasts with the poverty and inadequacies of the health component of the PSC-ERC agreement (https://www.redaccionmedica.com/autonomias/cataluna/aval-de-la-sanidad-catalana-a-pane-una-gestora-profesional-y-resolutiva–1002)
- Madrid will accredit six hospitals that treat cancer (https://elpais.com/espana/madrid/2024-08-17/madrid-pagara-270000-euros-para-acreditar-a-seis-hospitales-que-tratan-el-cancer-y-lo-vende-como-un-triunfo-frente-al-gobierno.html#:~:text=Madrid%2C%20que%20había%20presentado%20ocho,que%20le%20costará%20270.00)
- The works of the proton therapy center in Galicia have been partially completed (https://gacetamedica.com/politica/las-obras-del-centro-de-terapia-de-protones-de-la-xunta-de-galicia-ejecutadas-al-15/)
- In Asturias, the unattractive places that will have to be encouraged are quantified (https://www.lne.es/asturias/2024/08/12/salud-cuantifica-primera-vez-plazas-106905426.html)
- The debate on the fiscal pact in Catalonia and its impact on the SNS
- 63% of Spaniards believe that the fiscal pact in Catalonia will harm the rest of the autonomous communities (https://www.elindependiente.com/espana/2024/08/11/el-63-de-los-espanoles-considera-que-el-pacto-fiscal-en-cataluna-perjudicara-al-resto-de-comunidades-autonomas/)
- If the economic adjustment falls on other communities, their health will suffer (statements by the executive director of FEDEA) (https://www.consalud.es/autonomias/cupo-catalan-financiacion-sanidad-cc-aa_147378_102.html)
- Mpox in Spain
- The cases recorded in Spain are unvaccinated people (http://www.diariomedico.com/medicina/enfermedades-infecciosas/mpox-espana-casos-estan-registrando-son-personas-vacunar.html)
- Biosimilars
- The use of biosimilars increases by 6.1% and reaches a share of 72.8% in 15 drugs (https://diariofarma.com/2024/08/12/el-uso-de-biosimilares-aumenta-un-61#:~:text=Marketing%20Marketing-,El%20uso%20de%20biosimilares%20aumenta%20un%206%2C1%25%20y%20llega,gasto%20total%20hospitalario%20de%20medicamentos.)
- Mortality at work
- Mortality at work soars 7% until June, with 360 workers dead (https://elpais.com/economia/2024-08-08/la-mortalidad-en-el-trabajo-se-dispara-un-7-hasta-junio-con-360-trabajadores-fallecidos.html#)
Companies
- International news
- Eight superdrugs will lose their patents in the next five years. This affects Merck-MSD, BMS, Bayer, Pfizer, Lilly or Roche. The eight blockbusters that will lose their patent at the end of this decade are among the thirty best-selling drugs in the world (https://www.expansion.com/empresas/industria/2024/08/12/66b920e6468aebfe4a8b4576.html#)
- Pfizer-BioNTech’s combination of covid and flu vaccines fails in the last phase of the trial (https://www.ft.com/content/705af7c7-8333-4b54-9fe0-e0ed96d52706)
- AstraZeneca reaches a valuation of 200,000 million pounds (https://www.ft.com/content/2107bc0c-80e8-4eb0-9fc3-8093970ade4f)
- Who is Bavarian Nordic, the company that makes the only vaccine against Mpox, which rises by 10%? 38% on the stock market in four days. The CEO of this company, Paul Chaplin, assured that it will be able to meet the immunization needs of African nations. “We have inventory and we have the capabilities. What we lack are the orders,” he said (https://www.elconfidencial.com/empresas/2024-08-15/cotizacion-bavarian-nordic-fabricante-vacuna-viruela-mono-oms-disparada_3943716/)
- Bavarian Nordic will donate 40,000 doses of Mpox vaccines after the declaration of emergency in Africa (https://www.consalud.es/salud35/internacional/bavarian-nordic-dosis-vacunas-mpox-emergencia-africa_147485_102.html)
- Crown laboratories buys Revance Therapeutics for 924 million dollars (https://www.plantadoce.com/empresa/crown-laboratories-compra-revance-therapeutics-por-924-millones-de-dolares#:~:text=Nordisk%20MSD%20Astrazeneca-,Crown%20Laboratories%20compra%20Revance%20Therapeutics%20por%20924%20millones%20de%20dólares,Nasdaq%20al%20c)
- Lilly opens a state-of-the-art research and development center in Boston (https://www.plantadoce.com/empresa/lilly-abre-un-centro-de-investigacion-y-desarrollo-de-ultima-generacion-en-boston)
- National
- Black day for Grifols, a crash on the stock market and a lawsuit in the USA (https://www.elconfidencial.com/empresas/2024-08-14/jornada-negra-grifols-cae-bolsa-demanda-eeuu_3942675/)