7 days in healthcare (June, 10th-16th, 2024)
Summary
Biomedicine
- 40 years after the discovery of Helicobacter pylorii. The discovery of Helicobacter pylorii 40 years ago revolutionized the treatment of gastritis, peptic ulcer and stomach cancer, leading to Barry Marshall and Robin Warren being awarded the Nobel Prize in Medicine in 2005. This discovery transformed an incurable disease into one treatable with antibiotics. However, Helicobacter pylorii has a global prevalence of 35% among children and adolescents, especially in poor countries. This requires strengthening essential measures to reduce infection, such as hygiene education, water treatment and other health measures.
- The Lancet Editorial: Taking persistent physical symptoms seriously. These complex symptoms are incorrectly treated by health systems. Recognizing that they were misguided by the traditional biomedical model, in 1977 the biopsychosocial model was proposed, which has been criticized. Now a new model is proposed, as a starting point for a correct approach to this problem.
- The future of academic medicine. Academic medicine is in crisis globally, as demonstrated by commercial pressures and useless research and publications, which consume a lot of money. However, academic medicine is basic and science is the basis of medical practice and medical education. Evidence-based medicine, including research and practice, is the core element of academic medicine. The British Medical Journal launches a new global commission on the future of academic medicine.
Global Health
- Hopes for a pandemic treaty, despite the failure to meet the deadline. Along with the extension of the Pandemic Treaty deadline to 2025, an important partial agreement was reached: the review of rules to prevent the global spread of some infections. Even in the global Treaty, much progress was made, which allows for a certain optimism.
- Vaccine manufacturing is promoted in Africa. The African Vaccine Manufacturing Accelerator (AVMA), a new $1 billion+ initiative, an innovative financing mechanism designed by GAVI, offers African producers financial incentives to produce vaccines. The initiative will be launched at a high-level event in Paris.
- 10 years after the 2014-2016 Ebola epidemic in Africa. The crisis initially affected Guinea, Liberia and Sierra Leone and it took months to identify the cause and almost three years to contain it, after claiming thousands of lives. The epidemic revealed weak health systems, poor detection mechanisms and inadequate response. Since then, work has been done on preparation for these risks, response mechanisms and international collaboration.
International health policy
- Forecasts for 2023-32 healthcare expenditures in the United States. Healthcare spending is projected to grow faster than GDP growth over the next decade, reaching 19.7% of GDP in 2032 (from 17.3% in 2022). This indicates a large increase in the use of health services, linked to an increase in coverage that is estimated at 93.1% this year.
- The King’s Fund summarizes the manifestos of the different parties (Labour, Conservative and Liberal-Democratic) on health ahead of the elections. The different proposals are analyzed in relation to: social care reform; access to hospitals; access to primary care and community services; access to dental care; additional funding commitments; investments in capital and buildings; social care funding; training and selection of personnel; support to social services personnel; international recruitment and migration; prevention, inequities and public health; mental health, learning disabilities and autism; cancer; maternity and women’s health services; medicines, research and life sciences; digital transformation and technology; and, other proposals.
- “Aid in dying” in France. With the dissolution of the National Assembly, the “aid in dying” law is delayed indefinitely. With the call for elections, a very advanced legislative process declines, preceded by a great national debate with the personal intervention of President Macron.
- Advanced practice nursing in Belgium. A Royal Decree establishes the functions of advanced practice nursing, in an attempt to define different profiles of nurses and make the profession more attractive. Maybe a good lesson for Spain.
- Four industries responsible for 2.7 million deaths in Europe each year (7,400 per day): tobacco, alcohol, ultra-processed foods and fossil fuels.
National Health Policy (Spain)
- Public Management and Integrity Law. Competence doubts complicate the processing of this Law, which is surely good news, given the government’s intentions.
- Approved the law creating the Andalusian Health Institute. This is a new entity that brings together the Andalusian School of Public Health (EASP), the Progreso y Salud Foundation, as well as the General Secretariat of Public Health and R&D&I of the Ministry of Health, and will take the legal form of an agency. administrative and will have the nature of a public research organization. The headquarters will be in Seville, in the Ministry. Although we do not know the effects that this reform will have, the PP’s history in Andalusia of making public health companies disappear does not allow us to conceive much hope, on the contrary.
- Adeslas threatens to leave MUFACE if conditions do not improve. Given that Adeslas does not usually make statements lightly, it must be considered that there is a real risk of the system disappearing.
- Controversy over waiting for medications. Spain increases the wait for medicines, but improves availability, according to the WAIT report, prepared by the consulting firm IQVIA for the European Federation of Pharmaceutical Industries. The report says that in two years Spain has gone from 53% to 62% availability (compared to 88% in Germany or 77% in Italy), but the waiting time has gone from 629 to 661 days, almost two years of delay. On the other hand, César Hernández, general director of the Common Portfolio of the SNS and Pharmacy, criticizes the report and says that we are the country with the most access. The report does not take into account access through the mechanism provided for in RD 1015/2009, as well as medicines that arrive through clinical trials. Although the situation of access to medicines can surely be improved – and not only by the Ministry, but also by the intervention of the autonomous communities and hospitals – it does not seem that this issue is one of the most serious problems of the system, compared to what some they proclaim.
- Public Health Agency. The Health Commission of June 19 will not address the State Public Health Agency, which will not be analyzed by this Commission until after the summer. This is interpreted as another milestone in the long history of delays of this initiative.
- Center for Minority Diseases in Barcelona. Agreement between the Sant Joan de Deu Hospital and the Amancio Ortega Foundation for the launch of this center that will have financing of 60 million euros and will have a space of 14,000 square meters in a six-story building. With various genomics, metabolomics and radiomics platforms. The center will be part of the Red Única, a network made up of 30 hospitals throughout Spain and promoted by the Sant Joan de Deu Hospital and the Spanish Federation of Rare Diseases. Another great success for the Sant Joan de Deu Hospital, which many of us are already accustomed to.
Companies
- International
- Approved a new drug against Alzheimer’s. FDA panel approves Lilly’s Alzheimer’s drug. The modest benefits of Lilly’s drug donanemab outweigh the risks, the panel unanimously concludes.
- National
- Ribera incorporates the Covadonga Hospital in Gijón, with this incorporation there will now be six Spanish communities in which Ribera is present (Valencian Community, Murcia, Madrid, Galicia, Extremadura and Asturias).
- Terafront Pharmatech, the Spanish semi-public pharmaceutical company, will have its own factory. Terafront will manufacture its own therapies and has chosen to build its own facilities, compared to other options being considered.
Biomedicine
- 40 years after the discovery of Helicobacter pylorii. The discovery of Helicobacter pylorii 40 years ago revolutionized the treatment of gastritis, peptic ulcer and stomach cancer, leading to the Nobel Prize in Medicine in 2005 being awarded to Barry Marshall and Robin Warren. This discovery transformed an incurable disease into one treatable with antibiotics. However, Helicobacter pylorii has a global prevalence of 35% among children and adolescents, especially in poor countries. This requires strengthening education in hygiene, water treatment and other health measures, as essential to reduce infection (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01171-1/abstract)
- The Lancet Editorial: Taking persistent physical symptoms seriously. These complex symptoms are incorrectly treated by health systems. Recognizing that they were misguided by the traditional biomedical model, in 1977 he proposed the biopsychosocial model, which has been criticized. Now a new model is proposed, which is a starting point for a correct approach to this problem (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01242-X/fulltext)
- The FDA endorses a new drug against Alzheimer’s. This is the monoclonal antibody donanemab, a drug that removes amyloid beta protein from the brains of people with early Alzheimer’s and modestly slows their cognitive decline (https://www.science.org/content/article/fda-panel-backs-new-alzheimer-drug-despite-risks-uncertainties)
- The future of academic medicine. Academic medicine is in crisis globally, as demonstrated by commercial pressures and useless research and publications, which consume a lot of money. However, academic medicine is basic and science is the basis of medical practice and medical education. Evidence-based medicine, including research and practice, is the core element of academic medicine. The British Medical Journal launches a new global commission on the future of academic medicine (https://www.bmj.com/content/385/bmj.q1294)
- Nature article: CRISPR and ultra-rare diseases. When CAR-T began, it was thought to be so complex and expensive that it would be impossible to bring it to the clinic. Currently more than 30,000 people have been treated with CAR-T in the USA alone. Today, other therapies are on the horizon that would not long ago be considered impossible: an mRNA vaccine built for the genome of an individual tumor; the other is a genome-editing CRISPR therapy, created for a rare neurological disorder (https://www.nature.com/articles/d41586-024-01714-0.pdf)
- A pill with feces constitutes for the first time the antibiotic to treat serious infections (https://elpais.com/salud-y-bienestar/2024-06-13/una-pastilla-con-feces-sustitución-por-primera-time-antibiotic-to-treat-serious-infections.html#)
- An application allows you to calculate the risk of suffering from cancer (https://www.larazon.es/sociedad/aplicacion-permite-calcular-riesgo-padecer-cancer_2024061066673ce1b19e5e00014f0c03.html)
- A compound against malaria illuminates a way to treat polycystic ovary syndrome (https://elpais.com/salud-y-bienestar/2024-06-14/un-compuesto-contra-la-malaria-alumbra-una-way-to-treat-polycystic-ovarian-syndrome.html#). Access to the original article: https://www.science.org/doi/10.1126/science.adk5382
- Dual nanomedicine arrives: it attacks cancer cells and enhances the immune system (https://www.abc.es/salud/enfermedades/llega-nanomedicina-dual-ataca-celulas-cancerosas-poderas-20240614200000-nt.html#:~:text=Now%2C%20researchers%20of%20Brigham%20and,immunological%20to%20fight%20%20cancer.)
- The innovative tool that performs 100 tests in 8 minutes to detect eye pathologies (https://www.alimente.elconfidencial.com/bienestar/2024-06-14/innovadora-herramienta-probations-detectar-patologias-ojo_3896200/)
- Transplantation of stem cells from young mice delays Alzheimer’s in old mice (https://www.abc.es/salud/enfermedades/trasplante-celulas-madre-ratones-jovenes-retrasa-alzheimer-20240614084205-nt.html)
Global Health
- Hopes for a pandemic treaty, despite the failure to meet the deadline. Along with the extension of the Pandemic Treaty deadline to 2025, an important partial agreement was reached: the review of rules to prevent the global spread of some infections. Even in the Global Treaty, a lot of progress was made, which allows for a certain optimism (https://www.nature.com/articles/d41586-024-01658-5)
- Vaccine manufacturing is promoted in Africa. The African Vaccine Manufacturing Accelerator (AVMA), a new $1 billion+ initiative, an innovative financing mechanism designed by GAVI, offers African producers financial incentives to produce vaccines. The initiative will be launched at a high-level event in Paris (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01239-X/abstract#:~:text=The%20African%20Vaccine%20Manufacturing%20Accelerator%20(AVMA)%2C%20a%20new%20US,to%20produce%20vaccines%20at%20scale.)
- 10 years after the 2014-2016 Ebola epidemic in Africa. The crisis initially affected Guinea, Liberia and Sierra Leone and it took months to identify the cause and almost three years to contain it, after claiming thousands of lives. The epidemic revealed weak health systems, poor detection mechanisms and inadequate response. Since then, work has been done on preparation for these risks, response mechanisms and international collaboration (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00583-X/abstract)
International health policy
- USA
- Forecasts of 2023-32 health expenditures in the United States. Healthcare spending is projected to grow faster than GDP growth over the next decade, reaching 19.7% of GDP in 2032 (from 17.3% in 2022). This indicates a large increase in the use of health services, linked to an increase in coverage that is estimated at 93.1% this year (https://www.healthaffairs.org/doi/10.1377/hlthaff.2024.00469)
- United States: a health or healthcare economy? One interpretation is that the American healthcare system generates more jobs and spending, in part because it is inefficient and ineffective (https://www.ft.com/content/4a2cfd3b-f692-49df-9857-771e2e39d85b)
- The US Supreme Court rejects the ban on the abortion pill. In a unanimous decision by the “justices”, the Court opposes banning the pill, which is used in half of abortions in the USA (https://www.ft.com/content/fe1eb92b-8d50-4494-9f31-9a51a6fcdffd)
- Experts alarmed by the rise of non-hospital cesarean sections in Florida. A new law allows doctors to perform cesarean sections in “outpatient maternities,” contrary to what many believe that cesarean section always carries a risk, even life-threatening, and that it should never be performed outside of a hospital (https://www.nytimes.com/2024/06/15/health/ceseareans-outpatient-florida.html#:~:text=A%20new%20law%20in%20Florida,not%20be%20undertaken%20outside%20hospitals.)
- United Kingdom and the National Health Service
- The waiting list in the NHS in England grows to 7.57 million. Growth in April is a blow for Prime Minister Sunak (https://www.ft.com/content/b6d57d3c-e427-4e09-839a-04d350aa6038)
- The Labor Party calls for creating more than 100,000 nursing places (https://www.theguardian.com/politics/article/2024/jun/09/exclusive-labour-pledges-to-create-more-than-100000-new-nursery-places)
- The King’s Fund summarizes the manifestos of the different parties (Labour, Conservative and Liberal-Democratic) on health in view of the elections. The different proposals are analyzed in relation to: social care reform; access to hospitals; access to primary care and community services; access to dental care; additional funding commitments; investments in capital and buildings; social care funding; training and selection of personnel; support to social services personnel; international recruitment and migration; prevention, inequities and public health; mental health, learning disabilities and autism; cancer; maternity and women’s health services; medicines, research and life sciences; digital transformation and technology; and, other proposals (https://www.kingsfund.org.uk/insight-and-analysis/long-reads/health-care-manifesto-pledges-election-2024)
- France
- With the dissolution of the National Assembly, the “aid in dying” law is delayed indefinitely. With the call for elections, a very advanced legislative process declines, preceded by a great national debate with the personal intervention of President Macron (https://www.lemonde.fr/societe/article/2024/06/12/avec-la-dissolution-la-loi-sur-l-aide-a-mourir-menacee-d-effacement_6238960_3224.html)
- Belgium
- A Royal Decree establishes the functions of advanced practice nursing, in an attempt to define different profiles of nurses and make the profession more attractive (https://eurohealthobservatory.who.int/monitors/health-systems-monitor/updates/hspm/belgium-2020/advanced-practice-nurses-a-royal-decree-to-define-their-competencies). Access to the Royal Decree (in French and Flemish): https://organesdeconcertation.sante.belgique.be/sites/default/files/documents/ontwerpbesluit_apn_toegelaten_medische_handelingen_evenredigheidsbeoordeling.pdf
- Colombia
- The health crisis places President Petro against companies. For decades, private insurers (EPS) have been at the center of healthcare provision. The president is accused of bypassing Congress to advance his radical agenda (https://www.ft.com/content/c21bb499-cb9e-4469-9738-20ff44485a6e)
- European Union
- Four industries responsible for 2.7 million deaths in Europe each year (7,400 per day): tobacco, alcohol, ultra-processed foods and fossil fuels (https://www.lemonde.fr/planete/article/2024/06/12/quatre-industries-responsible-for-2-7-millions-de-morts-chaque-annee-en-europe-selon-l-organisation-mondiale-de-la-sante_6238948_3244.html)
- European Union secures purchase of 40 million doses of bird flu vaccine as cases rise (https://www.ft.com/content/467af193-a7f1-4957-9dfd-8e544fc8a05e)
- Major dispute in the EU over the European Parliament’s intention to relax the ban on the use of gene editing in crops. Gene editing has certain advantages, such as making crops more nutritious and resistant to pests (https://www.ft.com/content/5e3cc871-1377-4c65-88e5-e9096fb4db1f)
- In Europe, cases of dengue and diseases linked to mosquitoes have seen a notable increase (https://www.lemonde.fr/planete/article/2024/06/11/en-europe-les-cas-de-dengue-et-de-maladies-liees-aux-moustiques-connaissent-une-hausse-significant_6238745_3244.html#:~:text=Il%20s’agit%20d’une,(ECDC)%20dans%20un%20communiqué.)
- The EMA begins a review on the safety of Nolotil, the best-selling medicine in Spain (https://elpais.com/sociedad/2024-06-14/la-ema-inicia-una-revision-sobre-la-seguro -del-nolotil-the-best-selling-medicine-in-spain.html)
National health policy
- Central government initiatives
- An Interterritorial Council of mere procedure for the PP (https://www.diariomedico.com/medicina/politica/interterritorial-mero-tramite-pp-dia-marmota-ministra.html)
- Competence doubts complicate the processing of the Public Management and Integrity Law (https://www.redaccionmedica.com/secciones/ministerio-sanidad/la-injerencia-competencial-complica-la-ley-de-gestion-publica-del-sns-2032)
- The government ignores the ruling of the TSJUE and advances in the replacement of the interim ones (https://www.elconfidencial.com/economia/2024-06-14/gobierno-ignora-sentencia-tjue-reposition-interinos_3902611/#:~:text=The%20reason%20is%20that%20the,compensation%20according%20to%20harm%20caused.)
- Initiatives and news from the autonomous communities
- Approved the law creating the Andalusian Health Institute. This is a new entity that brings together the Andalusian School of Public Health (EASP), the Progreso y Salud Foundation, as well as the General Secretariat of Public Health and R&D&I of the Ministry of Health, and will take the legal form of an agency. administrative and will have the nature of a public research organization. The headquarters will be in Seville, in the Ministry (https://www.diariomedico.com/medicina/politica/aprobada-ley-crea-instituto-salud-andalucia.html)
- Catalonia will close 19% of hospital beds in August, but affirms that attendance will not suffer (https://elpais.com/espana/catalunya/2024-06-13/cataluna-cerrara-un-19-de-beds-in-August-but-ensures-that-hospital-care-will-not-be-resented.html#)
- MUFACE
- Adeslas threatens to leave MUFACE if conditions do not improve (https://www.epe.es/es/sanidad/20240613/adeslas-amenaza-muface-condiciones-mejoran-futuro-riesgo-convertir-103740457)
- The AiReF report on MUFACE will not be available until the end of the year (https://www.epe.es/es/sanidad/20240613/muface-informe-airef-viibilidad-estara-finales-ano-nuevo-convertir-103690240 )
- Discussion on the delay of medicines in Spain
- Spain increases the wait for medicines, but improves availability, according to the WAIT report, prepared by the consulting firm IQVIA for the European Federation of Pharmaceutical Industries. The report says that in two years Spain has gone from 53% to 62% availability (compared to 88% in Germany or 77% in Italy), but the waiting time has gone from 629 to 661 days, almost two years of delay (https://diariofarma.com/2024/06/12/wait-2023-espana-aumenta-la-espera-hasta-los-661-dias-pero-mejora-la-disponibilidad#). Access to the WAIT report published in June 2024: https://efpia.eu/media/vtapbere/efpia-patient-wait-indicator-2024.pdf
- On the other hand, César Hernández, general director of the Common Portfolio of the SNS and Pharmacy, criticizes the report and says that we are the country with the most access. The report does not take into account access through the mechanism provided for in RD 1015/2009, as well as medicines that arrive through clinical trials (https://diariofarma.com/2024/06/12/llego-el-dia-of-the-groundhog-with-wait-but-I-deny-the-greater-we-are-the-country-with-more-access#:~:text=%40diariofarma-“%20%20%20day%20%arrived 20the%20groundhog’%20with%20WAIT%2C,the%20innovation%20existing%20in%20Spain.)
- Public Health Agency
- The Health Commission of June 19 will not address the State Public Health Agency, which will not be analyzed by this Commission until after the summer. This is interpreted as another milestone in the long history of delays of this initiative (https://elglobal.es/politica/la-comision-de-sanidad-del-19-de-junio-no-abordara-la-agencia-state-public-health/#:~:text=The%20State%20Health%20Agency%20Public%20will%20not%20beaddressed%20at,point%20of%20order%20of%20day.)
- New hospitals in Madrid
- Under construction, 4 private; 0, public (https://elpais.com/espana/madrid/2024-06-15/nuevos-hospitales-en-obras-en-madrid-privados-4-publicos-0.html#)
- CSIC Biomedicine Strategic Plan
- The CSIC presents its Strategic plan in Biomedicine. This plan is based on 10 strategic axes, among which are: strengthening internal communication and collaboration between researchers; create new collaborative structures with companies, hospitals and universities; increase the presence of the CSIC in key international organizations; improve knowledge transfer to industry and the health sector; attract or retain young talent: Key actions: the creation of a Rare Diseases Network; the creation of a OneHealth Bassoon Library; the creation of the Biomed Transfer Services Network (https://www.consalud.es/saludigital/innovacion-tecnologica/csic-presenta-plan-estrategico-biomedicina-liderar-innovacion-en-salud_144755_102.html)
- National Cancer Research Center (CNIO)
- The CNIO achieves record turnover. Collaboration agreements with biotechnology and pharmaceutical companies on a global scale have generated income for the CNIO of almost 4 million euros in 2023 (https://www.plantadoce.com/empresa/centro-nacional-de-investigaciones-oncologicas-reaches-a-record-turnover)
- Center for minority diseases in Barcelona
- Agreement between the Sant Joan de Deu Hospital and the Amancio Ortega Foundation for the launch of this center that will have financing of 60 million euros and will have a space of 14,000 square meters in a six-story building. With various genomics, metabolomics and radiomics platforms. The center will be part of the Red Única, a network made up of 30 hospitals throughout Spain and promoted by the Sant Joan de Deu Hospital and the Spanish Federation of Rare Diseases (https://www.diariomedico.com/medicina/investigacion/primer-step-creation-pioneer-center-minority-diseases.html)
- Rise of new drugs in Spain
- Karkubi, the cheap drug from Morocco (https://www.larazon.es/sociedad/alerta-auge-jovenes-espanoles-karkubi-droga-barata-llegada-marruecos_20240615666dbe286a0d13000112adb8.html)
- Health professions
- Great push for healthcare FP. The academies, overwhelmed. The health vocational training has 13 cycles: three are of medium level and the rest are of higher level (https://elpais.com/extra/elige-tu-carrera/2024-06-16/el-tiron-de-la- fp-sanitary-overflows-the-academias.html)
Companies
- International News
- Moderna celebrates the success of the combined covid and flu vaccine trial (https://www.ft.com/content/c9576606-f0f7-4251-a2f0-25d2629e1485)
- FDA panel approves Lilly’s Alzheimer’s drug. Modest benefits of Lilly’s drug donanemab outweigh risks, panel concludes unanimously (https://www.nytimes.com/2024/06/10/health/alzheimers-treatment-donanemab.html)
- National
- The medical company Edwards Lifesciences chooses Valencia for its new factory with thousands of jobs (https://www.elespanol.com/valencia/economia/20240610/multinacional-medica-edwards-lifesciences-elige-valencia-nueva-fabrica-miles-jobs/861914018_0.html)
- Open war between Isdin and the OCU over a report on sunscreens (https://www.elconfidencial.com/empresas/2024-06-12/guerra-abierta-isdin-ocu-falso-informe-solares_3898606/)
- The new CEO of Grifols commits to achieving an EBIDTA of 1,800 million (https://www.elconfidencial.com/empresas/2024-06-14/ceo-grifols-alcanzar-ebitda-1-800-millones_3903190/#:~:text=The%20new%20advisor%20delegate%20of,%22plus%20of%201,800%20million%22.)
- Ribera incorporates the Covadonga Hospital in Gijón, with this incorporation there will now be six Spanish communities in which Ribera is present (Valencian Community, Murcia, Madrid, Galicia, Extremadura and Asturias) (https://www.consalud.es/salud35/national/ribera-avs-salud-agreement-incorporate-hospital-covadonga-grupo-sanitario_145193_102.html)
- The Insparya hair health group opens a center in Barcelona (https://www.plantadoce.com/empresa/grupo-insparya-cofundado-por-cristiano-ronaldo-abre-clinica-en-barcelona)
- Terafront Pharmatech, the Spanish semi-public pharmaceutical company, will have its own factory. Terafront will manufacture its own therapies and has chosen to build its own facilities, compared to other options being considered (https://www.plantadoce.com/empresa/terafront-pharmatech-la-farmaceutica-semipublica-espanola-tendra-fabrica-propria#:~:text=Almirall-,Terafront%20Pharmatech%2C%20la%20pharmaceutical%20semipublic%20española%2C%20willhave%20factory%20own,property%20of%20las)
- Spanish biotechnology companies invest 1,218 million in R&D and raise private financing of 228 million (https://cincodias.elpais.com/companias/2024-06-12/las-biotecnologicas-espanolas-invierten-1218-millones-en-id-y-captan-private-financing-for-228-millions.html)
- Almirall receives the green light to relaunch Klisyri in the USA (https://www.expansion.com/catalunya/2024/06/10/66674539e5fdeaeb4a8b4576.html#)