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7 days in healthcare (April 18-24, 2022)

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Summary

From the point of view of biomedicine, to highlight the new devices that read the brain (brain-reading-devices) and allow movement, touch and speech to be recovered. Also the great future of liquid biopsy in the early diagnosis of cancer.

As far as Global Health is concerned, there is no choice but to quote Bill Gates’ new TED video discussing how to avoid a new pandemic, which follows his previously celebrated video from 2015, five years before COVID-19. . Also the devastating effects of covid on the evolution of tuberculosis. It is highly worrying that in Africa there is a large backlog of vaccines, after multiple donations, which speaks of serious logistical problems. More than 100 confirmed cases in a dozen countries of the new acute childhood hepatitis of unknown origin.

Regarding international health policy, it should be noted that, according to the WHO, the incidence and mortality of COVID is falling globally. The United States will host the second global conference on COVID on May 12, 2022. Serious problems continue to arise in China, particularly in Shanghai, where respect for the most minimal freedoms collides with certain public health measures that are intended to be imposed. The new outbreak of covid in Beijing highlights the difficulty of following the “zero-covid” policy without many deaths, due to the low percentage of vaccination among the elderly in China and the less efficacy of the Chinese Sinovac vaccine, compared to that of Pfizer-Biontech.

If we talk about national health policy (Spain), although the incidence of COVID continues to grow, the mandatory use of the mask indoors has been abolished, which for some is premature. From the regulatory point of view, the Health Advertising Law and the Pharmacy Law of the Community of Madrid are announced, both with controversial components. The CNI warns of the large number of cyberattacks in health so far in 2022. The “Vanguard Health” Alliance is created to coordinate the health PERTE. Great media impact of the publication “Private healthcare, adding value” by the IDIS Foundation.

In the field of companies, from the international point of view, it is worth noting the movements of KKR to buy the largest hospital company in Australia (Ramsay). In our country, the position of the AESEG on the need to establish differential prices between generics and brands is important. Also the five-year agreement between the Junta de Andalucía and the Pascual Hospital Group.

Biomedicine

Global health

News international health policy

  • COVID-19

o According to the WHO, both the number of cases and mortality fell in the last week, following a decline from the end of March (https://www.theguardian.com/world/2022/apr/21/new-covid- cases-globally-down-by-nearly-a-quarter-last-week)

o The United States will host the second global summit on COVID. It will be online on May 12, 2022 (https://www.consalud.es/politica/eeuu-cumbre-mundial-pandemia-covid-19_113280_102.html)

o Shanghai wants to open factories with employees living in them (https://www.lavanguardia.com/internacional/20220418/8203602/shanghai-covid-china-pandemia-empresas-impacto.html)

o New COVID outbreak in Beijing. The Chinese authorities do not want the situation in Shanghai to be reproduced (https://elpais.com/sociedad/2022-04-24/pekin-toma-medidas-de-contencion-tras-detectar-un-subito-aumento-de -cases-of-covid.html)

  • Other themes

o The questioning of the authorization of abortion in the USA (Roe v Wade ruling), can cause serious health problems. It can increase the mortality of women in relation to pregnancy by 21% and 33% in black women (https://www.bmj.com/content/377/bmj.o1019). Many media worldwide denounce the toxicity of these restrictive laws (https://www.ft.com/content/a2b0d282-9baa-40ed-9a2c-64bbeaa5e375)

o New incentives are needed to fight antibiotic resistance, a pioneering subscription system in the UK can help improve the situation (https://www.ft.com/content/954d5e13-884e-4090-afca- 378993510558)

o Europe will not approve Biogen’s aducanumab for Alzheimer’s for now, approved in the USA by the FDA, amid great controversy (https://www.diariomedico.com/farmacia/industria/empresas/europa-no-aprobara-por-ahora- aducanumab-for-alzheimer.html)

News national health policy (Spain)

  • COVID

o The incidence of COVID continues to rise: 555.47 cases on Friday, April 22, in people over 60 years of age per 100,000 in the last 14 days, compared to 505.86 on Tuesday, April 19 (https://www.elconfidencial .com/espana/2022-04-22/espana-suma-49-143-cases-and-187-deaths-and-the-incidence-in-over-60s-up-50-points_3412937/)

o After 700 days, the Council of Ministers approves the no obligation to wear a mask indoors, with some exceptions (https://www.elmundo.es/ciencia-y-salud/salud/2022/04/19/625e955c21efa04b4d8b45d0.html)

o The majority of Spaniards believe that it is soon to remove the mask indoors (https://elpais.com/sociedad/2022-04-20/la-mayoria-de-los-espanoles-cree-que-es-pronto -to-remove-the-masks-indoors-and-continue-wearing-it.html)

o The XE variant of covid is already beginning to circulate in Spain (https://www.abc.es/sociedad/abci-variante-coronavirus-empuerta-circular-espana-202204202033_noticia.html)

o Great controversy over the distribution of antivirals (https://www.larazon.es/sociedad/20220421/yda2ugjo3rcszl56bzcp75rvvm.html)

  • Regulatory announcements

o The health advertising law, presented by the PP, to be examined in Congress. It is promoted by the Council of Dentists and also by the OMC (Doctors Order) (https://www.consalud.es/politica/parlamentos/ley-publicidad-sanitaria-pp-examen-congreso-semana_113468_102.html)

o Madrid approves the Pharmacy Law, among the novelties, it develops home distribution (closing the door to the delivery of medicines from entities outside pharmacies) and makes schedules more flexible (https://www.diariomedico.com/farmacia/politica/ madrid-approves-the-new-pharmacy-law-in-its-government-council.html). The Spanish Society of Hospital Pharmacy opposes this bill, for not contemplating hospital pharmacy in the regulations (https://www.diariofarma.com/2022/04/22/la-sefh-rechaza-la-loaf- Madrid)

  • Other themes

o Public healthcare spending skyrockets in 2020 due to the pandemic (https://www.plantadoce.com/entorno/el-sns-pisa-el-acelerador-tras-la-pandemia-y-dispara-el-gasto-sanitario -up-to-83811-million-euros.html)

o CNI alert: large number of cyberattacks in healthcare in 2022 (https://www.elespanol.com/invertia/observatorios/sanidad/20220422/alerta-cni-sanidad-publica-espanola-ciberataques-peligrosidad/666683412_0.html)

o The Fundación Instituto Roche addresses the involvement of the microbiome in maintaining health (https://www.actasanitaria.com/tecnologia/fundacion-instituto-roche-aborda-implicacion-microbioma_2002274_102.html). To access the full document: https://www.institutoroche.es/recursos/publicaciones/202/Hablando_sobre_microbioma

o The Ministry of Health reports eight cases of severe childhood hepatitis of unknown origin (https://www.eldiario.es/sociedad/sanidad-notifica-ocho-casos-hepatitis-aguda-infantil-origen-desconocido_1_8935838.html)

o The investigations for the purchase of masks already exceed ten (https://www.elperiodico.com/es/politica/20220423/investigaciones-contratos-mascarillas-covid-superan-decena-13553701)

o The “Salud de Vanguardia” Alliance is born to coordinate the health PERTE (https://www.diariofarma.com/2022/04/20/nace-la-alianza-salud-de-vanguardia-para-coordinar-el-perte -sanitary)

o Great impact of the document “Private healthcare, adding value” from the IDIS Foundation: https://www.fundacionidis.com/uploads/informes/informe_sanidad_privada_aportando_valor_2022.pdf.

Companies

  • International News

o The private equity firm KKR launches an offer for the largest Australian private hospital group, Ramsay (https://www.ft.com/content/ee5553e3-5d5c-4fbb-af4b-72dd9be0ef0a)

o GBL (Group Bruxelles Lambert) acquires the diagnostic imaging company Affidea, which at the time had acquired some assets in Spain (Q Diagnóstica) (https://www.plantadoce.com/empresa/gbl-adquiere-la-compania -of-medical-diagnostic-services-affidea.html)

o GSK, Sanofi and J&J accelerate spin offs in the pharmaceutical business (https://www.expansion.com/empresas/2022/04/19/625de599e5fdea36148b4677.html)

  • National News

o Generics: AESEG rejects the current plan for generics and biosimilars (made public, but not yet implemented due to the pandemic) if there is no price differential with brands (https://www.redaccionmedica.com/secciones/industria/el -generic-reformulates-the-national-plan-with-the-price-difference-as-axis-1032)

o The Junta de Andalucía signs a five-year agreement with the Pascual hospitals for an amount of 771 million euros (https://sevilla.abc.es/andalucia/sevi-junta-andalucia-firma-contrato-clinicas-pascual-cinco -hospitals-until-2027-771-millions-202203291523_noticia.html)

o DKV skyrockets its profits, largely due to the extraordinary results of the sale of its stake in the Denia hospital, acquired by Ribera (https://cincodias.elpais.com/cincodias/2022/04/20/companias/1650456633_959356 .html)

o Sacyr will build a pediatric center in Canada for more than 60 million euros (https://www.plantadoce.com/empresa/sacyr-construira-un-centro-pediatrico-en-canada-por-mas-de-60- million-euros.html)

o Atrys Health sprints on the Stock Market and targets revenues of 200 million in 2022 (https://www.plantadoce.com/empresa/atrys-health-sprints-on-the-continuo-y-apunta-a-incomes- of-220-million-euros-in-2022.html)

 

 

7 days in healthcare (January 31-February 6, 2022)

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SUMMARY

As far as biomedicine is concerned, the report on the value of death by The Lancet stands out; also the development of the nasal vaccine against COVID; the new horizon of transplants, derived from the possibilities of genetic editing of animal organs; and, the revolution that the new cancer vaccines based on mRNA technology may entail.

In terms of global health, the AstraZeneca vaccine is the most widely used worldwide, due to its contribution to COVAX. More than 2,500 million doses have been placed globally.

In international health policy, the most striking is the study by Johns Hopkins University, which minimizes the effectiveness of confinement, which contrasts with previous studies; the 900,000 deaths from COVID in the United States and the 500,000 in India; the WTO continues to request the release of vaccine patents. In Europe, it is worth highlighting the new clinical trial system approved by the European Union and its new approach to cancer.

National health policy continues to be dominated by COVID. The numbers of cases are decreasing, which speaks of the decline of the “sixth wave”. However, deaths are still very high. The announcement that oncological biomarkers will be included in the portfolio of the National Health System is very important. Cancer mapping in Spain presents very striking results, with a high concentration of cancer incidence in certain geographical areas. Subject to study and act.

In company news, the leading role of venture capital companies is notable, with the large operations underway by Sandoz (a generic and biosimilar branch of Novartis) and IVI (a Spanish fertility company). The interest of private equity companies is concentrated around these companies. Also the acquisition of MIR Asturias by CVC and the Alfonso X University. The attempt by Correos to enter pharmaceutical distribution will bring a tail.

BIOMEDICINE

  • Report on the value of death: while in developed countries there is hypertreatment around death, in most countries death occurs without access to basic pain treatment (The Lancet, January 31, 22)
  • The nasal vaccine may be better for successive doses. There are a dozen such vaccines in development in phase 3 trials (NYT, February 2, 22)
  • The “stealth” variant (stealth) does not generate alarm, but it can slow down the decline in the number of cases (NYT, January 31, 22)
  • The sub-variant “ómicron” BA.2, more contagious than the original (FT, 31 January 22)
  • The new variant BA.2, already present in 57 countries, according to the WHO (FT, February 3, 22)
  • New variant of the HIV virus, discovered in the Netherlands (FT, February 3, 22)
  • Genetic editing of pig hearts: a new horizon for transplants (FT, February 2, 22)
  • Cancer vaccines: the new mRNA revolution (El País, Vozpópuli, February 4, 22)
  • Amidst the wide debate on abortion, a simple pill seems the most viable option (The Economist, 5 February 22)

GLOBAL HEALTH

  • AstraZeneca, the most distributed vaccine through COVAX, has already given 2,500 million doses worldwide (ConSalud, January 31, 22)
  • Humanitarian groups denounce that sanctions against Mali may have very adverse health consequences (The Lancet, February 5, 22)

INTERNATIONAL HEALTH POLICY

  • COVID

o A study by Johns Hopkins University (Applied Economics Studies magazine) questions the effectiveness of confinement in reducing mortality, which contrasts with the analysis published in Nature in June 2020, which estimates that three million deaths have been prevented in Europe by confinement, 450,000 in Spain (El Independiente, February 3, 22)

o The UK approves the Novavax vaccine (FT, 3 February 22)

o The American army begins to fire its members who refuse the vaccine (The Guardian, February 2, 22)

o The New Zealand border will be reopened in phases from the end of February, the Prime Minister announces (The Guardian, 2 February 22)

o The United States reaches 900,000 deaths from COVID (The Guardian, February 4, 22)

o India exceeds 500,000 deaths from COVID (The Guardian, February 4, 22)

o Europe facing a “long period of tranquility” in the pandemic, says the WHO, due to the lesser severity of the “ómicron” variant, the high percentages of immunization and the good weather (The Guardian, February 3, 22)

o The WTO (World Trade Organization) wants an agreement to release vaccine patents this month (El Español, February 1, 22)

o The German Vaccine Commission recommends the fourth dose for vulnerable and health groups (El País, February 3, 22)

o Beijing seals off several communities for two cases of COVID (The Guardian, January 31, 22)

o The COVID vaccine is already mandatory in Austria, with a great social fracture (Expansión, February 5, 22)

  • Other issues

o New clinical trial system in Europe, which Farmaindustria sees as an opportunity (diariofarma, February 1, 22)

o The EU will act against inequalities against cancer (ConSalud, February 3, 22)

NATIONAL HEALTH POLICY (SPAIN)

  • COVID

o The sixth wave is being left behind, the cases and hospitalizations are slowing down, although not the deaths that already exceed 6,000 since November (El País, February 5, 22)

o The mask outdoors will no longer be mandatory from next Thursday (El País, February 4, 22)

o Health has not yet closed the purchase of 344,000 doses of Paxlovid (El Español, February 3, 22)

o The AEM authorizes the HIPRA vaccine to go to phase 3 of clinical trials (The Objective, February 1, 22)

  • Political ads

o The new public health center, affected by the decentralization of public offices (diariofarma, February 1, 22)

o The approval of oncological biomarkers, announced as a pending objective of the expansion of the NHS portfolio (diariofarma, February 1, 22)

o The Minister of Health says that the Anti-Tobacco Law needs to be updated (ConSalud, February 4, 22)

  • Other issues

o 27% of pharmaceutical innovations approved in 2021, subject to special financing conditions (diariofarma, February 1, 22)

o Access to new cancer drugs takes more than 19 months in Spain, while in Germany it takes two months, according to doctors and patients (La Vanguardia, February 2, 22)

o Health plan to make rural pharmacies more viable (ConSalud, January 28, 2022)

o The private e-prescription is consolidated (diariofarma, February 2, 22)

o The cartography of cancer in Spain has been published, with very striking results, according to the “Atlas of Cancer Mortality in Portugal and Spain” (El Periódico de España, February 5, 22)

COMPANIES, EMPLOYERS AND OTHER AGENTS IN THE SECTOR

  • American pharmaceutical companies (J&J and three of the largest drug distributors in the United States) agree to pay 590 million dollars to Native Americans for the opioid crisis (El País, February 1, 22)
  • Pharmaceutical cold distribution, new Correos service (Redacción Médica, February 2, 22)
  • Pfizer-Biontech requests authorization from the FDA for the approval of the vaccine for children under 5 years of age (El País, February 1, 22)
  • Private equity companies consider offers of more than 25,000 million dollars for the generics unit of Novartis, Sandoz, Blackstone, Carlyle and EQT, among the most interested (FT, February 1, 22)
  • KKR, CVC, Permira, Bain, Carlyle and PAI outline their bids to take over the fertility company of Valencian origin IVI, the bids range from 1,500 million euros (CincoDías, January 31, 22)
  • Atrys enters the continuous market, as of February 7 (PlantaDoce, February 3, 22)
  • Sanitas gains ground and plans to open 7 rehabilitation centers in 2022 (PlantaDoce, February 1, 22)
  • Adeslas and Caixabank extend their agreement in the Bankia network for 650 million euros (CincoDías, January 27, 22)
  • MIR Asturias acquired by CVC and Alfonso X University (La Nueva España, February 3, 22)
  • Quirón acquires Clínicas Vida and strengthens its care network in Tenerife (PlantaDoce, January 28, 22)
  • Vitaldent expands throughout Andalusia and opens a new clinic in Benalmádena (PlantaDoce, February 3, 22)
  • Group 5 opens a residence for serious mental disorders in Madrid (PlantaDoce, February 3, 22)
  • Prim is reinforced with the purchase of Herbitas laboratories (Expansión, February 4, 22)
  • Pharmamar leads a consortium of companies for the development of advanced therapies (El Economista, February 3, 22)