7 days in healthcare (September 15th-22nd, 2024)
Summary
Biomedicine
- Recognition for the scientists who developed anti-obesity drugs. Joel Habener (USA), Svetlana Mojsov (North Macedonia) and Lotte Bjerre Knudsen (Denmark), the parents of Ozempic, win the American Nobel Prize, the Lasker-DeBakey Prize for Clinical Medical Research 2024. Their scientific achievements are estimated to have allowed the discovery and development of FLP-1, the family of drugs that have revolutionized the treatment of obesity.
- Two technologies directly related to health among the 10 emerging technologies, according to the World Economic Forum: AI for scientific discoveries (including new drugs); and, genomics for transplants, which will allow the successful implantation of genetically modified organs.
- Schizophrenia, the new drug for the “cancer of psychiatry”. Hope is in sight, if the experimental drug KarXT is approved by the FDA, it will be the first treatment for schizophrenia in more than seven decades.
Global Health
- A global threat on the rise: antibiotic resistance. The problem threatens to kill 208 million people in 25 years. According to the report published in The Lancet, these infections will increase dramatically among those over 70 years of age. A global threat on the rise.
- The worst global health crisis is childhood malnutrition. New report from the Bill and Melinda Gates Foundation. More than 400 million children do not get the nutrients they need to grow and develop. Climate change makes this more difficult to solve.
- Strokes are skyrocketing worldwide. They already kill 7 million people, 70% more than in 1990. Most cases, up to 84%, are related to preventable risk factors.
International health policy
- Health has a big impact on the 2024 US elections. The affordability of American health care is a very important issue for voters this year, second only to the economy, according to a survey by the Kaiser Family Foundation. Both Trump and Biden during his presidency have made efforts in this direction. The former signed the “No surprises” law, to avoid unexpected bills from insurers; while Biden approved the “Inflation Reduction Act”, which allows Medicare to negotiate with pharmaceutical companies to set prices.
- British Prime Minister’s speech on health. He refers to the NHS saying: “reform or die”.
- End of the conflict and big salary increase for residents in England. They accept a 22% salary increase over the next two years.
- Controversial appointment of the new European Union Health Commissioner. Olivér Várhelyi, new European Commissioner for Animal Health and Welfare. The new commissioner – not yet ratified by Parliament – is Hungarian and very close to the ultra-nationalist Viktor Orbán.
National Health Policy (Spain)
- The new ALS law lacks funding. This makes it a dead letter. It seems that the application of the law will require 240 million a year, according to the confederation of ALS entities. Although ALS is a terrible disease and the sick require all the attention of the health system and this Law has generated great satisfaction among the sick and their families, it is more than debatable that the approach to health problems is to make specific laws for diseases. Why yes for ALS and not for quadriplegics, for example?
- The Government presents amendments to the Draft Law on the State Agency for Public Health. It seems that the government parties, PSOE and Sumar, have presented a text with new amendments to the Draft Law on the State Agency for Public Health, with a focus on health in all policies, as well as health determinants and a One Health approach. The private sector is also included when it comes to providing information. Although these elements sound very good, there may be some doubts that an effective and powerful Agency will be approved, in view of the composition of the government’s support, with nationalist parties always opposed to strengthening the State, except for the “State structures” themselves.
- Important speech by the Catalan Health Minister. She calls for 4 billion euros more in funding for the health sector. She advocates allocating 7% of the community’s GDP and reaching 20 billion euros, starting from the current 5.7%. According to her, Catalonia is the community that allocates the least percentage to Health (5.7%), only surpassed in this point by the community of Madrid (4.2%). In this appearance she presented the twelve priority objectives: 1. Healthy aging; 2. Integrated Social and Health Care; 3. Reinforcement of Primary Care; 4. Public Health; 5. Oral health and reduction of inequalities; 6. Certain measures regarding professionals; 7. Green agenda; 8. Digital transformation and innovation; 9. Evidence and evaluation; 10. Financing for the economic stability of the sector; and, 12. Reform and sustainability of the health system. Apart from the questionable approach of applying a percentage of GDP to health by communities (In which country is a percentage of GDP established by region for health care? This seems like a nationalist objective, directly translated from some of the approaches of the Pompeu Fabra University), the objectives seem reasonable, although perhaps a certain lack of ambition is lacking, particularly in the points referring to professionals and health system reforms.
- Galicia wants to become a reference bioregion. Galicia announces the creation of a knowledge transfer office for the biotechnology sector.
- Basque Country: commitment to reducing bureaucracy in Primary Care in 6 months. The objective is to reduce 40% of the bureaucratic activity that doctors must carry out in Primary Care.
- AIREF rejects bilateral negotiations on regional financing. Its president demands that financing be addressed jointly, to ensure that the measures taken do not affect sustainability.
- Disappointing new report on Spain from the European Observatory on Health Systems. The report has been prepared by the Aragonese Institute of Health Sciences. In general, the report has a descriptive character and is very little analytical and propositional. This is probably the focus of these reports from the European Observatory of Health Systems, but a more structured analysis methodology is missing, such as that used by Ezekiel Emanuel in his book on the analysis of health systems. It seems to be deduced from the report that everything is fine “except for a few things”, as Rajoy would say. It is not surprising that the Ministry of Health is applauding this report with its ears. Without a doubt, the high level of the authors is far above the results of the dispensable report.
Companies
- International
- The obesity market will have 16 new drugs in the next five years. Sales of these slimming drugs will reach 200 billion dollars in 2031, according to Morningstar. Although NovoNordisk and Lilly are currently the leaders and everything indicates that they will continue to be so, there will be many new entrants in this field: Boehringer Ingelheim, Zealand Pharma, Pfizer, Roche, Amgen and others.
- National
- Health insurance could raise prices due to rising costs. The increase in policies and the resulting increase in turnover barely manage to maintain the level of profitability
- Pharmaceutical company CINFA invests 40 million in a new factory in Navarra.
Biomedicine
- Scientists Joel Habener (USA), Svetlana Mojsov (North Macedonia) and Lotte Bjerre Knudsen (Denmark), the parents of Ozempic, win the American Nobel Prize, the Lasker-DeBakey Prize for Clinical Medical Research 2024. It is estimated that their scientific achievements have allowed the discovery and development of FLP-1, the family of drugs that have revolutionized the treatment of obesity (https://www.elmundo.es/ciencia-y-salud/salud/2024/09/19/66ec30dde9cf4a112a8b457c.html)
- The 10 emerging technologies in 2024 according to the World Economic Forum, including two directly related to health: AI for scientific discoveries (including new drugs); and, genomics for transplants, which will allow the successful implantation of genetically modified organs (https://www.weforum.org/publications/top-10-emerging-technologies-2024/)
- The promise of insulin only once a week for type 1 diabetes. Despite advances such as automatic delivery systems, patients with type 1 diabetes were subject to daily insulin injections. The innovation of delayed-acting insulin will allow these injections to be reduced to once a week (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01917-2/abstract)
- Divisions over lecanemab for the treatment of Alzheimer’s. Since Alois Alzheimer’s description more than a hundred years ago of the disease that now bears his name, the development of drugs that can alter the course of the disease is a monumental advance. Although lecanemab – a monoclonal antibody that acts against amyloid – has been approved by several regulators: FDA, Japan, China, Korea and Israel, the European Medicines Agency did not approve it, arguing that the benefits of the drug did not outweigh the possible harm. However, we will have to adopt an open-minded position to the results (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02075-0/fulltext)
- Schizophrenia, the new drug for the “cancer of psychiatry”. Hope in sight, if the experimental drug KarXT is approved by the FDA, it will be the first treatment for schizophrenia in more than seven decades (https://www.ft.com/content/427d37df-e2e9-4b67-87be-29f2a258de00)
- Strong relationships between alcohol and cancer are described in a new report. Adults under 50 are experiencing increasing rates of breast and colorectal cancer. Alcohol may be one of the causes behind this trend. The report warns that 40% of cancers may be associated with modifiable risk factors (https://www.nytimes.com/2024/09/18/health/alcohol-cancer-young-adults.html). Access to the original document: https://cancerprogressreport.aacr.org/progress/
- An antidepressant attacks the deadliest brain tumor: glioblastoma. Scientists have discovered that vortioxetine, an antidepressant, effectively fights glioblastomas in the laboratory. Clinical trials are already in preparation (https://www.abc.es/salud/enfermedades/antidepresivo-ataca-tumor-cerebral-mortal-glioblastoma-20240920124203-nt.html). Access to the original document: https://www.nature.com/articles/s41591-024-03224-y
- Immunotherapy achieves unusual survival rates in a handful of tumors (https://elpais.com/salud-y-bienestar/2024-09-16/la-inmunoterapia-logra-supervivencias-insolitas-en-un-punado-de-tumores.html)
- Blood tests and precision medicine change Alzheimer’s detection overnight (https://www.consalud.es/pacientes/avances-alzheimer-un-analisis-sangre-resultado-similar-otras-pruebas_148707_102.html)
- A new map of the endometrium opens the door to finding new treatments for endometriosis. The research involves advanced molecular biology and AI techniques, and will allow us to better understand this disease about which very little is known and which affects 190 million women and has no cure (https://elpais.com/salud-y-bienestar/2024-09-19/un-nuevo-mapa-del-endometrio-abre-la-puerta-a-encontrar-posibles-tratamientos-a-la-endometriosis.html)
Global Health
- Antibiotic resistance, the problem that threatens to kill 208 million people in 25 years. According to the report published in The Lancet, these infections will increase dramatically among those over 70 years of age. A global threat on the rise (https://elpais.com/salud-y-bienestar/2024-09-16/la-resistencia-a-los-antibioticos-el-problema-que-amenaza-con-matar-a-208-millones-de-personas-en-25-anos.html). Access to the original article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01867-1/fulltext
- The worst global health crisis is child malnutrition, new report from the Bill and Melinda Gates Foundation. More than 400 million children do not get the nutrients they need to grow and develop. Climate change makes this harder to solve (https://www.gatesfoundation.org/goalkeepers/report/2024-report/)
- The coming microbial crisis (https://www.science.org/doi/10.1126/science.ads3473)
- Strokes are skyrocketing worldwide, killing 7 million people, 70% more than in 1990. Most cases, up to 84%, are related to preventable risk factors (https://www.elespanol.com/ciencia/salud/20240919/ictus-disparan-mundo-matan-millones-personas/886911850_0.html)
International Health Policy
- USA
- The impact of health on the 2024 American elections. The affordability of American health care is a very important issue for voters this year, second only to the economy, according to a survey by the Kaiser Family Foundation. Both Trump during his presidency, and Biden, have made efforts in this direction. The former signed the “No surprises” law, to avoid unexpected bills from insurers; while Biden approved the “Inflation Reduction Act”, which allows Medicare to negotiate with pharmaceutical companies to set prices (https://sph.emory.edu/features/2024/presidential-election/health-policy/)
- The FTC (Federal Trade Commission) accuses Middlemen (the largest Pharmacy Benefit Managers) of inflating insulin prices (https://www.nytimes.com/2024/09/20/health/ftc-drug-price-inflation-insulin.html)
- China
- From superhospitals with 7,000 beds to ship-hospitals (http://diariomedico.com/medicina/profesion/china-superhospitales-7000-camas-hospitales-barco.html)
- United Kingdom and the National Health Service
- The British Prime Minister refers to the NHS saying: “reform or die” (https://www.bmj.com/content/386/bmj.q2001)
- Any NHS reform must avoid mistakes of 2012 (https://www.bmj.com/content/386/bmj.q2041)
- Resident doctors agree to 22% pay rise over next two years (https://www.bmj.com/content/386/bmj.q2038)
- Junk food ads to be banned before 9pm (https://www.bmj.com/content/386/bmj.q2006)
- France
- Centrist Geneviève Darriessecq, new health minister, inherits a sector in crisis (https://www.lemonde.fr/politique/article/2024/09/21/a-la-sante-la-centriste-genevieve-darrieussecq-herite-d-un-secteur-en-crise_6327117_823448.html)
- Hospital crisis: saturated emergency rooms, bed closures and other problems (https://www.lemonde.fr/societe/article/2024/09/17/crise-de-l-hopital-urgences-saturees-fermetures-de-lits-place-des-cliniques-les-dossiers-en-attente-d-un-ministre_6320867_3224.html)
- Afghanistan
- European Union
- Olivér Várhelyi, new European Commissioner for Animal Health and Welfare. This appointment is controversial. The new commissioner – not yet ratified by Parliament – is Hungarian and very close to the ultra-nationalist Viktor Orbán (https://www.lavanguardia.com/vida/20240921/9956815/oliver-varhelyi-nuevo-polemico-nuevo-comisario-bienestar-animal.html)
- Brussels proposes that smoking be banned on terraces and in restaurants (https://www.elmundo.es/ciencia-y-salud/salud/2024/09/17/66e98a1ffdddffb9ab8b459f.html)
National health policy
- Central government initiatives
- ALS sufferers warn that the new law lacks funding, so it may be a dead letter. It seems that the application of the law will require 240 million a year, according to the confederation of ALS entities (https://www.elmundo.es/ciencia-y-salud/salud/2024/09/18/66e9699afdddff32a98b45b5.html)
- The Ministry of Health promises again that it will incorporate glasses into the portfolio of services (https://www.epe.es/es/sanidad/20240916/sanidad-incluira-gafas-cartera-servicios-monica-garcia-salud-bucodental-108203273)
- Sumar includes the taxation of health insurance in its proposal for the General State Budget for 2025 (https://diariofarma.com/2024/09/16/sumar-lleva-la-tributacion-de-los-seguros-sanitarios-a-su-propuesta-de-pge-para-2025)
- Royal Decree on Technology Assessment: the allegations are being studied (https://www.consalud.es/politica/ministerio-sanidad/rd-evaluacion-tecnologias-sanitarias-avanza-es-hora-estudiar-alegaciones_148678_102.html)
- The Government presents amendments to the Draft Law of the State Agency for Public Health. It seems that the government parties, PSOE and Sumar, have presented a text with new amendments to the Draft Law of the State Agency for Public Health, with a focus on health in all policies, as well as health determinants and a One Health approach. The private sector is also included when providing information (https://gacetamedica.com/politica/el-gobierno-presenta-enmiendas-al-proyecto-de-ley-de-la-agencia-estatal-de-salud-publica/)
- The Ministry of Health limits the professionals who can perform cosmetic surgery (https://elpais.com/sociedad/2024-09-21/sanidad-limita-la-cirugia-estetica-solo-a-los-medicos-especialistas-en-esta-practica.html)
- Initiatives and news from the autonomous communities
- Madrid breaks its record for pending medical appointments again (https://elpais.com/espana/madrid/2024-09-16/madrid-bate-de-nuevo-su-record-de-citas-medicas-en-espera-10297(https://elpais.com/espana/catalunya/2024-09-18/la-consejera-de-salud-quiere-reforzar-el-sistema-sanitario-catalan-con-unos-4000-millones-de-euros-mas.html).
- The Minister of Health of Catalonia asks for 4,000 million more in financing for the health sector. She defends allocating 7% of the GDP of the community and reaching 20,000 million, starting from the current 5.7%. According to her, Catalonia is the community that allocates the least percentage to Health (5.7%), only surpassed in this point by the community of Madrid (4.2%). In this appearance, she presented the twelve priority objectives: 1. Healthy aging; 2. Integrated Social and Health Care; 3. Strengthening Primary Care; 4. Public Health; 5. Oral health and reducing inequalities; 6. Certain measures regarding professionals; 7. Green agenda; 8. Digital transformation and innovation; 9. Evidence and evaluation; 10. Financing for the economic stability of the sector; and, 12. Reform and sustainability of the health system (https://elpais.com/espana/catalunya/2024-09-18/la-consejera-de-salud-quiere-reforzar-el-sistema-sanitario-catalan-con-unos-4000-millones-de-euros-mas.html). Access to the official document of the appearance on the Department’s website: https://salutweb.gencat.cat/ca/inici/nota-premsa/?id=655062
- Catalan doctors urge Pané to create a new health model outside of political ups and downs, within the framework of the National Health Pact of Catalonia (https://www.consalud.es/autonomias/cataluna/medicos-catalanes-urgen-pane-necesidad-nuevos-avances-en-pacto-nacional-salud_148569_102.html)
- Galicia announces the creation of a knowledge transfer office for the biotechnology sector, to turn Galicia into a reference bioregion (https://elglobal.es/politica/galicia-anuncia-la-creacion-de-una-oficina-transferencia-de-conocimiento-para-el-sector-biotecnologico/)
- Asturias announces a pact for Mental Health (https://www.redaccionmedica.com/autonomias/asturias/asturias-negocia-un-gran-pacto-politico-de-salud-mental-es-fundamental–7359)
- Basque Country: commitment to reducing bureaucracy in Primary Care in 6 months. The objective is to reduce 40% of the bureaucratic activity that doctors must carry out in Primary Care (http://www.diariomedico.com/medicina/politica/pais-vasco-compromiso-reduccion-40-burocracia-ap-seis-meses.html)
- Osakidetza will launch a special OPE only for positions that are difficult to fill, there will be more than 100 positions and loyalty and permanence in these positions will be encouraged (https://www.redaccionmedica.com/autonomias/pais-vasco/osakidetza-lanzara-una-ope-especial-solo-para-plazas-de-dificil-cobertura-9524)
- AIREF and the Catalan agreement
- AIREF rejects bilateral negotiations on regional financing. Its president demands that financing be addressed jointly, to ensure that the measures taken do not affect sustainability (https://www.larazon.es/economia/airef-rechaza-negociacion-bilateral-financiacion-autonomica_2024091766e9baeefcf7b3000137a12e.html)
- New report on Spain from the European Observatory on Health Systems
- The report has been prepared by the Aragonese Institute of Health Sciences. In general, the report has a descriptive character and is very little analytical and propositional. This is surely the approach of these reports from the European Observatory on Health Systems, but a more structured analysis methodology is missing, such as that used by Ezekiel Emanuel in his book on the analysis of health systems. It seems to be deduced from the report that everything is fine “except for a few things”, as Rajoy would say. It is not surprising that the Ministry of Health is applauding this report with its ears (https://www.consaludmental.org/publicaciones/Health-System-Review-2024.pdf)
- Dengue in Tarragona
- The number of cases of dengue in Tarragona has risen to eight (https://elpais.com/sociedad/2024-09-17/ascienden-a-ocho-los-casos-de-dengue-en-el-brote-de-tarragona-que-ya-es-el-mayor-registrado-en-espana.html)
- Health insurance
- A saturated market with “low cost” offers (https://www.plantadoce.com/entorno/un-mercado-ocupa-y-con-ofertas-low-cost-radiografia-de-los-seguros-medicos-en-espana)
- Medical places
- Students and deans oppose the latest increase in Medicine places (https://www.consalud.es/formacion/estudiantes-decanos-se-oponen-ultima-ampliacion-plazas-medicina-no-es-coherente_148553_102.html)
- Pharmaceutical industry
- The requests of the pharmaceutical industry to be incorporated in the future regulation of the sector (https://elglobal.es/politica/las-peticiones-de-la-industria-farmaceutica-a-incorporar-en-la-futura-regulacion-del-sector/)
- Spending on oncological therapies
- Global spending on oncological therapies soars by 83% until 2028 (https://cincodias.elpais.com/extras/ciencia-salud/2024-09-21/el-gasto-global-en-terapias-oncologicas-se-dispara-un-83-hasta-2028.html)
- Nursing homes
- Three quarters of the beds are private and there is a lack of coordination with the public sector (https://www.elmundo.es/ciencia-y-salud/salud/2024/09/19/66eafa05fc6c8353618b45a4.html)
Companies
- International News
- The obesity market will have 16 new drugs in the next five years. Sales of these weight loss drugs will reach 200 billion dollars in 2031, according to Morningstar. Although NovoNordisk and Lilly are currently the leaders and all indications are that they will remain so, there will be many new entrants in this field: Boehringer Ingelheim, Zealand Pharma, Pfizer, Roche, Amgen and others (https://www.elespanol.com/invertia/observatorios/sanidad/20240922/mercado-obesidad-contara-nuevos-medicamentos-proximos-anos/887411322_0.html)
- Weight-loss drugs have changed the culture (https://www.economist.com/culture/2024/09/19/weight-loss-drugs-have-changed-culture)
- AstraZeneca and MSD announce progress in cancer treatment, in particular in bladder cancer and certain forms of breast tumors (https://www.ft.com/content/0064325b-941e-4680-94d7-b02c4ea10c45)
- National
- Gaes incorporates 31 new centres after the purchase of the Andalusian company OIRT (https://www.plantadoce.com/empresa/gaes-incorpora-31-nuevos-centros-tras-la-compra-de-la-andaluza-oirt)
- Pharmaceutical company CINFA invests 40 million in a new factory in Navarra (https://www.eleconomista.es/salud/noticias/12990686/09/24/la-farmaceutica-cinfa-invierte-40-millones-en-una-nueva-fabrica-en-navarra.html)
- Kern Pharma invoices 16% more and gains weight in the foreign market (https://www.expansion.com/catalunya/2024/09/15/66e71f16468aeb2a078b459d.html)
- Health insurance could raise prices due to rising costs. The increase in policies and the resulting increase in turnover barely manage to maintain the level of profitability (https://www.expansion.com/empresas/seguros/2024/09/16/66e75992e5fdead82c8b4582.html)
- Alantra enters the dental business with 13 laboratories (https://www.expansion.com/empresas/2024/09/17/66e88107468aeb4a028b459f.html)