7 days in healthcare (September 23rd-29th, 2024)
Summary
Biomedicine
- Organ donation, lessons from the Spanish model. Transplantation is the only valid treatment for the failure of certain organs and can transform the lives of these patients. According to the Global Observatory on Donations and Transplants, only 10% of the global demand for transplants is met. Transplant ratios vary greatly between countries, from 130 per million in the USA and Spain to 12 in India. In May 2024, a new WHO resolution was approved. The leader in donations is Spain, and success is based on three facts: a solid legislative framework; strong clinical leadership and very good logistics, organized by the National Transplant Organization.
- Immunotherapy, a promise for the treatment of many diseases. The so-called CAR-T was first used in leukemia. The technique consists of extracting T cells, genetically modifying them and then returning them to the patient’s body. This therapy can be applied to asthma, heart disease and even for aging.
- Article by Eric J Topol in Science. The revolution of high-throughput proteomics and AI. The recent ability to measure hundreds of plasma proteins from small blood samples may facilitate a new way of understanding human disease. The company SomaLogic has developed the means to measure more than 10,000 proteins. When this data is integrated with other information, we obtain relevant information about diseases.
Global Health
- A global threat on the rise: antibiotic resistance. The problem threatens to kill 208 million people in 25 years. According to the report published in The Lancet, these infections will increase dramatically among those over 70 years of age. A global threat on the rise.
- The global weight of antimicrobial resistance and the outlook for 2050. Antimicrobial resistance (AMR) is known as a global emergency that requires the concerted effort of all stakeholders. The statistical analysis of the study published by The Lancet says that mortality from AMR will rise to 8.22 million by 2050.
- Antimicrobial resistance may be more deadly than cancer, according to Ara Darzi (Lord Darzi of Denham, author of the recent report on the NHS)
International health policy
- The FDA approves the first drug against schizophrenia in decades. Until now treatments blocked dopamine receptors, with strong side effects. The new drug Cobenfy influences dopamine levels, but as an indirect effect.
- Several British health think tanks comment on the speech of the Minister of Health: King’s Fund, Nuffield Trust and Health Foundation.
- Jordan, the first country to eliminate leprosy. According to the WHO, Jordan is the first country to eliminate leprosy, still present in more than 120 countries.
National Health Policy (Spain)
- The Ministry of Health will meet again with the pharmaceutical sector’s employers’ associations to finalise the loose ends of the Strategic Plan. The objective is still to publish the Plan next October.
- The Generalitat of Catalonia is preparing a committee of experts (called Cairós) to reform its health system, which will be chaired by Manel del Castillo. Its objective will not be to draw up documents, but to evaluate policies. There is no doubt that the technical and professional level of the new Catalan government health team is exceptional, as has not been the case for years. It is important for the whole of Spain that they succeed, as they can contribute to unblocking and addressing certain basic issues of the system from a different perspective, such as the management model and the staff regime in the SNS, which, surprisingly, are not on the agenda of the central government or the regional governments. However, technical qualification is a prerequisite for success, but not a guarantee. From a general point of view, it is difficult to remain optimistic about the political situation of the Catalan and central governments.
- The best employment after the MIR, community by community. The objective is that the 7,500 residents who finish do not leave their training community. Economic incentives and long-term contracts are the main offers.
- Management of sick leave by the Mutual Societies. The door is opened for the autonomous communities to agree on the management of sick leave with the Mutual Societies for Work Accidents in traumatological processes. The measure could contribute to improving the management of sick leave, according to FEDEA.
Companies
- International
- Big pharma is abandoning new antibiotics: 81% are already being developed by SMEs. This is the conclusion of a long study published by Nature Reviews Microbiology.
- Statements by the global CEO of Lilly: if Europe cuts patents, there will be no more investments.
- National
- Psychology, a “big business” about to explode due to growth without criteria or quality. Psychology is the career that has grown the most in number of students in the 21st century. There is a risk of producing a factory of unemployed, given the scarce presence of Psychology in the NHS.
Biomedicine
- Organ donation, lessons from the Spanish model. Transplantation is the only valid treatment for the failure of certain organs and can transform the lives of these patients. According to the Global Observatory on Donations and Transplants, only 10% of the global demand for transplants is met. Transplant ratios vary greatly between countries, from 130 per million in the USA and Spain to 12 in India. In May 2024, a new WHO resolution was approved. The leader in donations in Spain, and success is based on three facts: a solid legislative framework; strong clinical leadership and very good logistics, organized by the National Transplant Organization (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02128-7/fulltext?rss=yes)
- Immunotherapy, a promise for the treatment of many diseases. The so-called CAR-T was first used in leukemia. The technique involves extracting T cells, genetically modifying them, and then returning them to the patient’s body. This therapy can be applied to asthma, heart disease, and even aging (https://www.economist.com/science-and-technology/2024/09/25/immune-therapy-shows-promise-for-asthma-heart-disease-and-even-ageing)
- How digital twins are going to revolutionize medicine. According to this article in Science, it is possible to build virtual personalized models that can be considered digital twins, which can predict individual risks and response to therapy (https://www.science.org/doi/10.1126/science.ads7922)
- Article by Eric J Topol in Science. The revolution of high-throughput proteomics and AI. The recent ability to measure hundreds of plasma proteins from small blood samples may facilitate a new way of understanding human disease. SomaLogic has developed the means to measure more than 10,000 proteins. When this data is integrated with other information, we obtain relevant information about the diseases (https://www.science.org/doi/10.1126/science.ads7922)
- Preventing Alzheimer’s disease through sport should be a priority for public health policies. According to geriatrician Olivier de Ladoucette, regular physical activity reduces the risk of developing this pathology (https://www.lemonde.fr/idees/article/2024/09/27/la-prevention-de-la-maladie-d-alzheimer-par-le-sport-devrait-etre-une-priorite-des-politiques-de-sante-publique_6336685_3232.html#:~:text=En%20conclusion%2C%20le%20sport%20apparaît,être%20une%20stratégie%20p)
- Silencing genes using the RNA technique will make it possible to treat a wide variety of pathologies. Although RNA therapies became known to the general public through the COVID vaccine, this technique can also be applied to cancer and also has the possibility of silencing the expression of specific genes to prevent the production of proteins that cause a disease (https://www.consalud.es/industria/silenciar-genes-estrategia-arn-tratar-gran-variedad-patologias_148971_102.html)
Global Health
- MPox vaccination underway, while cases continue to rise. Despite vaccination programmes in African countries such as Rwanda and Burundi, cases continue to rise (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02132-9/abstract?rss=yes#:~:text=Bavarian%20Nordic’s%20MVA%2DBN%20has,support%20Africa’s%20response%20to%20mpox.)
- Population ill-prepared for climate crisis. According to the International Labour Organisation (ILO), the lack of social protection is the biggest problem for protecting the population from climate change. The most threatened countries (16 of which are in Africa), more than 91% of the population lack any form of social protection (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02133-0/abstract?rss=yes)
- The global burden of antimicrobial resistance and the outlook for 2050. Antimicrobial resistance (AMR) is known as a global emergency that requires the concerted effort of all stakeholders. The statistical analysis of the study published by The Lancet says that AMR mortality will rise to 8.22 million in 2050 (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01885-3/abstract#:~:text=Using%20this%20model%2C%20authors%20estimate,65)%20associated%20deaths%20in%202050.)
- Ara Darzi (Lord Darzi of Denham, author of the recent report on the NHS) says that antimicrobial resistance may be more deadly than cancer (https://www.economist.com/by-invitation/2024/09/23/ara-darzi-on-why-antibiotic-resistance-could-be-deadlier-than-cancer)
- A future pandemic as big as covid is inevitable, says UK Chief Medical Officer Prof. Whitty’s survey (https://www.theguardian.com/uk-news/2024/sep/26/future-pandemic-as-big-as-covid-is-inevitable-says-whitty
International health policy
- USA
- Possible cluster of human bird flu infections expanding in Missouri (https://www.nytimes.com/2024/09/27/health/bird-flu-cluster-missouri.html)
- Joe Biden announces offer of one million mpox vaccines to Africa (https://www.lemonde.fr/afrique/article/2024/09/25/les-etats-unis-vont-offrir-un-million-de-doses-de-vaccin-contre-la-mpox-a-l-afrique-annonce-joe-biden_6332869_3212.html)
- FDA approves first drug against schizophrenia in decades. Until now, treatments blocked dopamine receptors, with strong side effects. New drug Cobenfy influences dopamine levels, but as an indirect effect (https://www.nytimes.com/2024/09/26/health/fda-schizophrenia-drug.html)
- Arcadia psychiatric hospital network accused of unethical practices for keeping patients in longer than medically necessary (https://www.nytimes.com/2024/09/26/health/acadia-doj-settlement-fbi.html)
- United Kingdom and the National Health Service
- Several British health think tanks comment on the speech of the Minister of Health. Original King’s Fund note: https://www.kingsfund.org.uk/insight-and-analysis/press-releases/secretary-state-health-speech-labour-party-conference Original Nuffield Trust note: https://www.nuffieldtrust.org.uk/news-item/response-to-wes-streetings-labour-conference-speech Health Foundation note: https://www.health.org.uk/news-and-comment/news/health-foundation-responds-to-wes-streetings-labour-conference-speech
- Pharmacy closures in England threaten plan to use them instead of GPs. A total of 436 community pharmacies have closed in the last year and many more have been temporarily closed (https://www.theguardian.com/society/2024/sep/26/pharmacy-closures-in-england-threaten-plan-to-use-them-instead-of-gps-for-some-care)
- Only 4.3% of stroke patients in England have access to life-saving treatments (https://www.theguardian.com/society/2024/sep/29/only-43-of-stroke-patients-in-england-can-access-life-saving-treatment)
- France
- A dozen laboratories condemned for not having built up sufficient stocks (https://www.lemonde.fr/economie/article/2024/09/24/penuries-de-medicaments-8-millions-d-euros-d-amendes-pour-11-laboratoires-pharmaceutiques_6331133_3234.html#:~:text=Dans%20une%20décision%20rare%2C%20le,maintien%20de%20stocks%20de%20sécurité.)
- Jordan
- Jordan, the first country to eliminate leprosy. According to the WHO, Jordan is the first country to eliminate leprosy, which is still present in more than 120 countries (https://www.bmj.com/content/386/bmj.q2069)
- European Union
- Mpox: almost 90% increase in cases in Europe in August, with Spain at the head (https://www.epe.es/es/sanidad/20240923/viruela-del-mono-oms-informa-aumento-90-casos-europa-espana-108459953)
- Great controversy in Europe due to the non-approval of lecanemab, the controversial drug against Alzheimer’s. The United States, China, Japan, Israel, South Korea or the United Arab Emirates have already approved it. According to the Spanish Society of Neurology, which advocates for its approval, it would only benefit 5% of patients (https://elpcom/ciencia/2024-09-25/rebelion-cientifica-para-que-europa-apruebe-el-controvertido-medicamento-contra-el-alzheimer.html)
- The European Investment Bank allocates 1.5 billion euros to improve health systems. The initiative is part of the WHO project to improve primary care services (https://www.consalud.es/politica/banco-europeo-inversiones-millones-mejorar-sistemas-sanitarios_148785_102.html)
National health policy
- Central government initiatives
- The Ministry of Health will meet again with the pharmaceutical sector’s employers’ associations to finalise the loose ends of the Strategic Plan. The objective remains to publish the Plan next October (https://www.elespanol.com/invertia/observatorios/sanidad/20240925/sanidad-volvera-reunir-patronales-sector-farmaceutico-cerrar-flecos-plan-estrategico/888411372_0.html)
- The Ministry of Health approves the funding of two drugs for metastatic breast cancer. These are the drugs Enhertu and Trodelvy, whose approval had been rejected up to four times (https://www.lavanguardia.com/vida/20240926/9973604/sanidad-aprueba-financiacion-dos-farmacos-cancer-mama-metastasico.html)
- The first Strategic Plan of the Observatory against Fraud and Corruption in Health has been approved (http://diariomedico.com/medicina/politica/aprobado-primer-plan-estrategico-observatorio-fraude-corrupcion-sanitaria.html)
- The Ministry establishes a new language requirement for the homologation of non-EU doctors (https://www.redaccionmedica.com/secciones/medicina/el-gobierno-regulara-el-nivel-de-espanol-exigido-al-medico-extracomunitario-6518#:~:text=“Nos%20ha%20sorprendido%20la%20exigencia,ha%20tenido%20acceso%20Redacción%20Médica.)
- The Ministry will meet with EU ministers to centralize drug purchases (https://www.eleconomista.es/salud/noticias/13004067/09/24/sanidad-se-reunira-con-los-ministros-de-la-ue-para-centralizar-compras-de-medicamentos.html)
- Initiatives and news from the autonomous communities
- The Generalitat of Catalonia is preparing a committee of experts (called Cairós) to reform its health system, which will be chaired by Manel del Castillo. Its objective will not be to prepare documents, but to evaluate policies (https://www.plantadoce.com/publico/la-generalitat-de-cataluna-prepara-un-comite-de-expertos-para-reformar-su-sistema-de-salud)
- Catalan medical students present their manifesto against the opening of more faculties (https://www.consalud.es/autonomias/cataluna/estudiantes-medicina-catalanes-presentan-su-manifiesto-contra-apertura-mas-facultades_148876_102.html)
- The fight for new medical schools that divides Castilla y León (https://www.elconfidencial.com/espana/castilla-y-leon/2024-09-27/pugna-nuevas-facultades-medicina-castilla-leon_3970822/)
- The best job after the MIR, community by community. The aim is to ensure that the 7,500 residents who graduate do not leave their training community. Economic incentives and long-term contracts, the main offers (https://www.redaccionmedica.com/secciones/formacion/mapa-de-una-espana-que-retiene-a-sus-mir-de-contratos-anuales-a-incentivos-7347)
- Galicia strengthens its alliance with pharmacists to improve out-of-hospital care (https://elglobal.es/politica/galicia-refuerza-su-alianza-con-los-farmaceuticos-para-mejorar-la-atencion-extrahospitalaria/)
- Waiting lists soar in Asturian healthcare, despite overtime (https://www.lne.es/asturias/2024/09/29/listas-espera-sanidad-asturiana-disparan-108693595.html)
- MUFACE
- The IDIS Foundation predicts a loss of 13,000 jobs if the agreement is not renewed (https://www.epe.es/es/sanidad/20240926/muface-sanidad-privada-augura-perdida-trabajo-renovacion-concierto-108595265). Access to the original report by the IDIS Foundation: https://www.fundacionidis.com/informes/analisis-de-situacion-de-la-sanidad-privada/impacto-de-las-mutualidades-en-el-sistema-sanitario
- Sick leave and Work Accident Mutual Societies
- Management of sick leave by Mutual Societies. The door is opened for the autonomous communities to agree on the management of sick leave with Work Accident Mutual Societies in traumatological processes. The measure could contribute to improving the management of sick leave, according to FEDEA (https://www.redaccionmedica.com/secciones/sanidad-hoy/dos-peros-lastran-el-positivo-avance-de-la-gestion-de-bajas-por-mutuas-5408). Original FEDEA report on the subject: https://documentos.fedea.net/pubs/ap/2024/ap2024-25.pdf?utm_source=wordpress&utm_medium=portada&utm_campaign=estudio
- CEOE and health VAT
- The CEOE think tank calls for reducing VAT on health products to be on par with Europe (https://elpais.com/economia/2024-09-27/el-think-tank-de-la-ceoe-pide-reducir-el-iva-de-los-productos-sanitarios-para-equipararse-a-europa.html#)
- Voluntary terminations of pregnancy
- 103,097 terminations of pregnancy in 2023, of which 4.7% were in women under 20 years of age (http://www.diariomedico.com/medicina/politica/103097-interrupciones-embarazo-2023-9394-peticion-mujer.html)
Companies
- International news
- Big pharma abandons new antibiotics: 81% are already being developed by SMEs. This is evident from a long study published by Nature Reviews Microbiology (https://theobjective.com/economia/2024-09-27/grandes-farmaceuticas-abandonan-desarrollo-nuevos-antibioticos/#:~:text=El%20Liberal%20%2D%20Economía-,Las%20grandes%20farmas%20abandonan%20los%20nuevos%20antibioticos%3A%20el%2081,ya%20los%20desarrollan%20las%)
- Bavarian Nordic signs an agreement with UNICEF to distribute one million mpox vaccines (https://www.consalud.es/salud35/internacional/bavarian-nordic-firma-acuerdo-con-unicef-distribuir-millon-vacunas-mpox_148955_102.html)
- The global CEO of Lilly He says that if Europe cuts patents, there will be no more investments (http://www.diariomedico.com/medicina/empresas/dave-ricks-lilly-sera-catastrofico-europa-recorta-patentes-vendran-nuevas-inversiones.html#:~:text=Dave%20Ricks%20(Lilly)%3A%20%22It will be, a%20more%20favorable%20political%20framework.)
- National
- Recoletas is increasing its reproductive business with two new clinics in Santander and Navarra (https://www.plantadoce.com/empresa/recoletas-entra-en-calidad-de-socio-unico-en-dos-clinicas-reproductivas-en-santander-y-navarra)
- Psychology, a “big business” about to explode due to growing without criteria or quality. Psychology is the career that has grown the most in number of students in the 21st century. There is a risk of producing a factory of unemployed, given the scarce presence of Psychology in the SNS (https://www.consalud.es/profesionales/psicologia-gran-negocio-punto-explotar-crecer-sin-criterio-ni-calidad_148946_102.html)
- The CNMV opens a disciplinary file to Grifols for defects in financial information (https://cincodias.elpais.com/companias/2024-09-25/la-cnmv-abre-expediente-sancionador-a-grifols-por-defectos-en-la-informacion-financiera-y-en-los-informes-de-gestion.html)
- Homedoctor opens its shareholding to the funds Q-Impact and Clave Capital (https://www.eleconomista.es/capital-riesgo/noticias/13003462/09/24/homedoctor-abre-su-accionariado-a-los-fondos-qimpact-y-clave-capital.html)