7 days in healthcare (September 2nd-8th, 2024)
Summary
Biomedicine
- Prostate cancer incidence in Europe: beware of overdiagnosis. The conclusion of an article published in the BMJ is that the incidence of prostate cancer varies very significantly in the different countries of Europe (rates of 46 in Ukraine to 336 in France, per 100,000 inhabitants). The incidence began to decline in some countries. The interpretation of screening must be very cautious, to avoid damage due to overdiagnosis.
- The Lancet review on obesity in adults. It has increased in incidence worldwide and the WHO has declared it a global epidemic. Complex disease. Lifestyle changes only produce lasting improvement in a minority of patients. Bariatric surgery remains the most effective and long-lasting treatment. Very notable progress has been made in the field of pharmacology.
- AI raises hopes for a better diagnosis of cancer, based on pathological anatomy. The model is called the Clinical Histopathology Imaging Evaluation Foundation (CHIEF) and was developed by Harvard Medical School. This tool, published in Nature, is trained to analyze tumor images, covering 19 cancers.
Global Health
- Temperature-related mortality analyzed in Europe. The Lancet Public Health publishes a review led by David García-León on the consequences of heat and cold in 854 European cities.
- Avian influenza in humans, without previous exposure. The CDC confirms the first avian influenza patient without known exposure.
International health policy
- The failed experiment of primary care as a for-profit enterprise in the USA. Although for some time it was thought that primary care could be a lucrative business for investors, including private equity firms, the latest evidence does not support this hope in the USA, possibly because current payment systems do not adequately value primary care. This is also causing basic primary care centers in shopping centers, which Walmart was a pioneer of, to close.
- The new British Health Minister’s best wishes. The British Health Minister says that the NHS is not broken, but it needs three major changes: “from hospital to community”, “from analogue to digital” and from “disease to prevention”. As a desideratum it is perfect, now we have to see how it is implemented. These are not exactly plans that the NHS lacks.
- King’s Fund explains GP contracts for 2024-25. Apart from salary increases for different concepts, an incentive scheme is maintained (for quality, The Quality and Outcomes Framework; for investments and for experience in access).
- Uruguay introduces a controversial hospital law. Law 20,279 reinforces forced admission to hospitals without the patient’s consent, in cases of homeless people, mental health problems or addictions. Humanitarian and professional organisations, against it.
- The European Union is not fully prepared for the next health crisis, warns the auditing body. A report by the European Court of Audit shows that a lack of coordination between Member States in terms of information and testing slowed down the US response to the Covid-19 outbreak and warns that greater cooperation is needed to address future crises.
National Health Policy (Spain)
- The Ministry is already looking for a date to publish the Strategic Plan for the Pharmaceutical Industry, with the idea of establishing a framework for collaboration between the different agents.
- State Agency for Public Health, likely to be delayed indefinitely. The government has 44 key laws in limbo, including that of the State Agency for Public Health, due to the lack of support in Congress.
- Metges is opposed to the creation of new Faculties of Medicine in Catalonia, because it thinks that adding more university centres “would increase saturation and decrease teaching quality”. It is considered that there is a risk of having a surplus of doctors again, as in the 1980s. The challenge, according to this organisation, is that the 1,000 doctors who graduate in Catalonia decide to stay here to practice their profession. The number of Faculties of Medicine in Spain per 100,000 inhabitants is only surpassed by South Korea. Are many of them Faculties of Medicine or academies specialising in the MIR exam?
- Galicia launches the Xenoma project to detect diseases with AI, an initiative that will collect the DNA of 400,000 Galicians to identify high-risk genetic variants and be able to offer personalized pharmacological treatments.
- The autonomous communities compete to retain MIRs. In La Rioja, Castilla y León, Aragón or the Valencian Community, there are plans to offer advantageous conditions to residents so that they stay.
- Are there too many dentists in Spain? Job insecurity among dentists. In 2023, the number of registered professionals reached 42,075 professionals; that is 9,630 more than ten years ago (2013), an increase of 29.7%.
- It seems that there will be no Profarma plan in 2024. The new Profarma will arrive in 2025 and will assess the aspects of strategic autonomy. This program is more than 30 years old and provides tax exemptions for pharmaceutical companies that contribute the most to GDP through their activity. This plan, which was in effect for more than three decades, will surely not be in force in 2024.
- Catalonia promotes the PRECISEU project led by Biocat. PRECISEU, a giant step towards personalized medicine in Europe. Endowed with 23 million euros, the project wants to promote personalized medicine and advanced therapies in Europe. The project has 25 partners and will last until 2029.
Companies
- International
- Investment in cancer does not cover all types. Large disparities in pharmaceutical investments in relation to the types of cancer. While new treatments for breast, lung and prostate cancer have appeared in recent years, other tumours, also with a high mortality rate, are less well-neglected, such as pancreatic tumours, colon tumours or brain tumours.
- National
- Farmaindustria attacks the European pharmaceutical reform for hindering innovation, because it is thought to be a threat to the competitiveness of European companies, compared to American or Chinese ones, according to Jesús Ponce.
Biomedicine
- BMJ article: Prostate cancer incidence and mortality in Europe. The conclusion is that the incidence of prostate cancer varies significantly in different countries in Europe (rates from 46 in Ukraine to 336 in France, per 100,000 inhabitants). The incidence began to decline in some countries. The interpretation of screening must be very cautious, to avoid damage from overdiagnosis (https://www.bmj.com/content/386/bmj-2023-077738)
- The Lancet review. Obesity in adults. It has increased in incidence worldwide and the WHO has declared it a global epidemic. A complex disease. Lifestyle changes only produce lasting improvement in a minority of patients. Bariatric surgery remains the most effective and long-lasting treatment. There has been progress in the field of pharmacology (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01210-8/abstract#:~:text=The%20prevalence%20of%20obesity%20has,%25%20of%20adults)%20by%202030.)
- Gene therapy in the early stages of retinal degeneration. Gene therapy is very promising in these cases, since vision loss is functional and potentially reversible (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01853-1/abstract)
- First, do not harm. Second, Measure It. Although the first sentence comes from Hippocrates in the 4th century BC, in this day and age we need to measure damage, to compare, improve and guide research (https://www.amjmed.com/article/S0002-9343(24)00281-X/fulltext)
- NEJM article: A late but welcome arrival of sarcoma therapy. So far, progress in the treatment of sarcomas has been very slow, as they represent only 2% of all cancers and there are 70 subtypes of sarcoma, with different responses to drugs. (https://www.nejm.org/doi/full/10.1056/NEJMe2407116?rss=searchAndBrowse)
- AI raises hopes for better cancer diagnosis. The model is called Clinical Histopathology Imaging Evaluation Foundation (CHIEF) and was developed by Harvard Medical School. This tool, published in Nature, is trained to analyze tumor images, covering 19 cancers (https://www.ft.com/content/0a8f2c61-77f4-43ce-87d2-a7b421bbda85). Access to the original Nature article: https://www.nature.com/articles/s41586-024-07894-z
- A study identifies five distinct ways of aging thanks to data from 50,000 brain scans (https://elpais.com/salud-y-bienestar/2024-09-03/un-estudio-identifica-cinco-formas-distintas-de-envejecer-gracias-a-los-datos-de-50000-escaneres-cerebrales.html). Original article from Nature Medicine: https://www.nature.com/articles/s41591-024-03144-x
- Neuroscience 2.0 artificial intelligence and a cap to diagnose Alzheimer’s in its early stages (https://www.elmundo.es/ciencia-y-salud/salud/2024/09/06/66d9eeece9cf4a9d5c8b4575.html)
- The polypill arrives, 3 drugs in 1, for high blood pressure (https://www.abc.es/salud/enfermedades/llega-polipildora-farmacos-hipertension-arterial-20240902133837-nt.html#)
- New and expensive cancer drugs offer hope to patients, but with great strain on health budgets. This is triggering the emergence of new forms of reimbursement, for example, the pharmaceutical company will bear the cost of the first four months of use and, if proven effective, the insurer (public or private) will continue to pay for the treatment (https://www.ft.com/content/4dfc5540-da29-4701-b773-6e02b4c71a1e)
Global Health
- Temperature-related mortality. The Lancet Public Health publishes a review led by David García-León on the consequences of heat and cold in 854 European cities (https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(24)00184-1/fulltext#:~:text=The%20number%20of%20cold%2Drelated,or%20older%20in%20southern%20Europe.)
- Natural solutions to the climate crisis, such as restoring tropical forests or wetlands (https://www.thelancet.com/journals/lanonc/article/PIIS0140-6736(24)01599-X/abstract)
- CDC confirms first avian flu patient with no known exposure (http://www.diariomedico.com/medicina/enfermedades-infecciosas/cdc-confirman-primer-paciente-gripe-aviar-expósito-conocida.html)
International health policy
- USA
- The use of e-cigarettes in the USA is falling to levels from ten years ago. The data comes from the National Youth Tobacco Survey (https://www.nytimes.com/2024/09/05/health/e-cigarettes-teenagers-vaping.html)
- In the United States, 1,300 newborns have died due to the use of pesticides, according to a study published by the journal Science. (https://www.lemonde.fr/planete/article/2024/09/05/aux-etats-unis-la-disparition-des-chauves-souris-a-accru-l-usage-des-pesticides-augmentant-la-mortalite-infantile_6305064_3244.html). Access to the original article: https://www.science.org/doi/10.1126/science.adg0344
- The failed experiment of primary care as a for-profit enterprise. Although for some time it was thought that primary care could be a lucrative business for investors, including private equity firms, the latest evidence does not support this hope in the USA, possibly because current payment systems do not adequately value primary care. This is also leading to the closure of primary care centres in shopping centres, pioneered by Walmart (https://www.healthaffairs.org/content/forefront/failing-experiment-primary-care-profit-enterprise)
- United Kingdom and the National Health Service
- The English Health Minister says that the NHS needs three big changes: “from hospital to community”, “from analogue to digital” and from “disease to prevention” (https://www.ft.com/content/1e71c913-4dea-4088-878e-4d3e2889b875)
- The decline in the number of GPs threatens the continuity of care in the UK. It is unrealistic that with the falling number of GPs, half of all appointments in England will be with primary care doctors can be maintained (https://www.theguardian.com/society/article/2024/sep/04/nhs-faces-tipping-point-in-england-where-most-appointments-will-not-be-with-gps). Access to the original BMJ article: https://bmjopen.bmj.com/content/14/8/e081535
- King’s Fund: Primary care networks explained (https://www.kingsfund.org.uk/insight-and-analysis/long-reads/primary-care-networks-explained)
- King’s Fund: GP contracts for 2024-25 explained. Apart from salary increases for different concepts, an incentive scheme is maintained (for quality, The Quality and Outcomes Framework; for investments and for experience in access) (https://www.kingsfund.org.uk/insight-and-analysis/long-reads/gp-contract-2024-25-explained#:~:text=and%20contracts%20explained.-,Overall%20funding%20in%20the%202024%2F25%20GP%20contract,GPs%20and%20other%20practice%20staff)
- The British government is considering banning smoking in open spaces (https://www.bmj.com/content/386/bmj.q1908#:~:text=Health%20leaders%20have%20welcomed%20news,outdoor%20restaurants%2C%20and%20hospital%20grounds.)
- France
- French health authorities recommend a booster vaccination against mpox (https://www.lemonde.fr/planete/article/2024/09/02/mpox-les-autorites-sanitaires-francaises-recommandent-un-rappel-vaccinal-pour-lutter-contre-le-risque-d-une-nouvelle-flambee-epidemique_6302214_3244.html)
- The High Authority authorizes reimbursement under the conditions of the Mounjaro (https://www.lemonde.fr/sante/article/2024/09/06/antiobesite-et-antidiabetique-la-haute-autorite-de-sante-autorise-le-remboursement-sous-conditions-du-mounjaro_6305800_1651302.html)
- Uruguay
- Uruguay introduces controversial hospital law. Law 20,279 reinforces forced hospital admission without patient consent, in cases of homelessness, mental health problems or addictions. Humanitarian and professional organizations are against it. (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01862-2/abstract)
- European Union
- The European Union is not fully prepared for the next health crisis, warns the audit body. A report by the European Court of Audit shows that a lack of coordination between member states on information and testing slowed down the US response to the Covid-19 outbreak and warns that greater cooperation is needed to tackle future crises (https://www.ft.com/content/ca61f33c-8bf8-40d3-90e4-d417b04e224d)
National health policy
- Central government initiatives
- The Ministry is already looking for a date to publish the Strategic Plan for the Pharmaceutical Industry, with the idea of establishing a framework for collaboration between the different agents (https://www.elespanol.com/invertia/observatorios/sanidad/20240903/sanidad-busca-fechas-publicar-plan-estrategico-industria-farmaceutica-preve-octubre/882911893_0.html)
- The government has 44 key laws in limbo, including that of the State Agency for Public Health, due to the lack of support in Congress (https://theobjective.com/espana/politica/2024-09-07/sanchez-cajon-44-leyes-clave-congreso/)
- The RD on the price and financing of medicines will be put out for public consultation this year, with the idea of it being approved in 2025 (https://elglobal.es/politica/el-rd-de-precio-y-financiacion-de-medicamentos-saldra-a-consulta-publica-este-ano-con-la-intention-de-aprobarse-en-2025/)
- Initiatives and news from the autonomous communities
- Pradales advances in his Basque Health Pact, “beyond the waiting lists” (https://www.consalud.es/autonomias/pais-vasco/pradales-pone-primera-piedra-su-pacto-vasco-salud-que-va-mas-alla-listas-espera_148126_102.html)
- The PP asks to put aside the “linguistic imposition in the Basque Health Pact” (https://www.consalud.es/autonomias/pais-vasco/pp-pide-aparcar-imposicion-linguistica-hora-buscar-pacto-vasco-salud_148161_102.html)
- Metges is opposed to the creation of new medical schools in Catalonia, because it believes that adding more university centres “would increase saturation and decrease teaching quality”. It is considered that there is a risk of having a surplus of doctors again, as in the 1980s. The challenge, according to this organization, is that the 1,000 doctors who graduate in Catalonia decide to stay here to practice their profession (https://www.consalud.es/autonomias/cataluna/metges-se-opone-creacion-nuevas-facultades-medicina-en-cataluna_148120_102.html)
- Galicia starts the Xenoma project to detect diseases with AI, an initiative that will collect the DNA of 400,000 Galicians to identify high-risk genetic variants and be able to offer personalized pharmacological treatments (https://www.redaccionmedica.com/autonomias/galicia/galicia-inicia-el-proyecto-xenoma-para-detectar-enfermedades-con-la-ia-3211#)
- This is how the autonomous communities compete to retain MIRs. In La Rioja, Castilla y León, Aragón and the Valencian Community, there are plans to offer advantageous conditions to residents to stay (https://www.consalud.es/autonomias/compiten-ccaa-seducir-retener-mir-ultimo-ano_148063_102.html)
- Health coverage
- Neither the PSOE nor the PP have ensured universal coverage in 40 years, according to the Bioethics Committee of Spain (https://www.elmundo.es/ciencia-y-salud/salud/2024/09/05/66d83617e4d4d8a1138b456d.html). Access to the report of the Bioethics Commission of Spain: https://comitedebioetica.isciii.es/wp-content/uploads/2024/09/CBE_Informe_sobre_el_acceso_universal_al_sistema_sanitario_2024_30.07.2024.pdf
- Are there too many dentists in Spain?
- Job insecurity among dentists. In 2023, the number of registered professionals reached 42,075; that is 9,630 more than ten years ago (2013), an increase of 29.7% (https://www.epe.es/es/sanidad/20240905/dentistas-espana-contratos-temporales-salarios-bajos-competencia-feroz-incremento-descontrolado-107777523). Access to the report of the Council of Dentists on the demographics of dentists in Spain 2000-2024: https://consejodentistas.es/wp-content/uploads/2024/09/DEMOGRAFIA-DE-LOS-DENTISTAS-EN-ESPANA.-2024-Definitivo.pdf
- Profarma Plan
- The new Profarma will arrive in 2025 and will assess the aspects of strategic autonomy. This program is more than 30 years old and provides tax exemptions for pharmaceutical companies that contribute the most to GDP through their activity. This plan, which has been in force for more than three decades, will probably not be in force in 2024 (https://diariofarma.com/2024/09/05/nuevo-profarma-no-llegara-hasta-2025-y-valorara-aspectos-de-autonomia-estrategica)
- Catalonia is promoting the PRECISEU project led by Biocat
- PRECISEU, a giant step towards personalized medicine in Europe. Endowed with 23 million euros, the project aims to promote personalized medicine and advanced therapies in Europe. The project has 25 partners and will last until 2029 (https://www.consalud.es/pacientes/proyecto-preciseu-medicina-personalizada-espana_148173_102.html).
Companies
- International news
- Investment in cancer does not cover all types. Large disparities in pharmaceutical investments in relation to cancer types. Just as new treatments for breast, lung and prostate have appeared in recent years, other tumors, also with high mortality, are more neglected, such as pancreatic tumors, or colon or brain tumors (https://www.expansion.com/economia/financial-times/2024/09/07/66dc38a0468aeb315e8b4596.html)
- Universal Health Services, from start-up to healthcare giant in the USA and the United Kingdom (https://www.plantadoce.com/adn/universal-health-services-from-start-up-to-six-employees-to-giant-in-the-usa-and-united-kingdom)
- Novonordisk’s weight-loss drugs, responsible for half of Denmark’s GDP (https://www.eleconomista.es/salud/noticias/12970974/09/24/los-farmacos-para-adelgazar-de-novo-nordisk-seran-culpables-de-la-mitad-del-pib-de-dinamarca.html)
- AstraZeneca admits that a small number of its employees are under investigation in China (https://www.ft.com/content/f5970ecc-c524-461f-bf7e-c00f30f5bf37)
- National
- Farmaindustria attacks the European pharmaceutical reform for hindering innovation, because it is thought to be a threat to the competitiveness of European companies, compared to American or Chinese ones, according to Jesús Ponce (https://www.eleconomista.es/salud/noticias/12973611/09/24/farmaindustria-carga-contra-la-reforma-europea-por-lastrar-la-innovacion.html)
- Roche will restructure its companies in Spain during the ERE (https://www.plantadoce.com/empresa/roche-reestructura-sus-sociedades-en-espana-en-pleno-ere)
- Farmadosis, a Mallorcan company specializing in hardware and software for pharmacies and hospitals, acquires the British Medpoint to grow in the United Kingdom (https://www.plantadoce.com/empresa/farmadosis-adquiere-la-britanica-medpoint-para-crecer-en-el-reino-unido)